This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
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TAB-174 | Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Mouse IgG1, κ |
TAB-1611CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) | Depletion, FuncS | Mouse Fab |
TAB-1620CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HD37) | FuncS | |
TAB-1622CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1622CL-F(E)) | ELISA, FC, Apop, ADCC, FuncS | Mouse Fab |
TAB-1623CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1623CL-F(E)) | ELISA, FC | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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