Recombinant Humanized monoclonal antibody expressed in CHO binding to Human CD44. RG7356 is a humanized antibody targeting the constant region of CD44 that shows antitumor efficacy in mice implanted with CD44-expressing tumors such as MDA-MB-231 breast cancer cells. Short-term treatment of tumor-bearing mice with RG7356 resulted in modifications of the MAPK pathway in the responsive model, although no effects on downstream phosphorylation were observed in a nonresponsive xenograft model.
Figure 1 RG7356 serum concentration versus time plot in patients in Arm A who received the biweekly (q2w) (A) and weekly (qw) (B) dosing schedules.
Menke-van der Houven, C. W., van Oordt, C. G. R., van Herpen, C., Coveler, A. L., Mahalingam, D., Verheul, H. M.,... & Cannarile, M. A. (2016). First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors. Oncotarget, 7(48), 80046.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-727 | Anti-CD44 Recombinant Antibody (Bivatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
TAB-236LC | Anti-Human CD44 Recombinant Antibody (huPTA-4621) | FuncS | Humanized antibody |
TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-239LC | Human Anti-CD44 Recombinant Antibody (TAB-239LC) | FC | Human IgG |
TAB-226LC-S(P) | Human Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-226LC-S(P)) | WB, ELISA | Human scFv |
TAB-227LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (1A9.A6.B9) | FC, ELISA | Human antibody |
TAB-228LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (2D1.A3.D12) | FC, ELISA | Human antibody |
TAB-239LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-239LC-F(E)) | FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-231LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P)) | ELISA | Mouse scFv |
TAB-232LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-232LC-S(P)) | ELISA | Mouse scFv |
TAB-231LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-232LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-232LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-235LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (chPTA-4621) | FC | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0101MZ | Chicken Anti-CD44 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-378CQ | Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) | FC, IF, Inhib, IP, WB | Rat IgG2b |
NEUT-381CQ | Human Anti-CD44 Recombinant Antibody (clone Hermes-3) | ELISA, FC, IF, IHC, IP, Neut, WB | Human IgG1, κ |
NEUT-382CQ | Rat Anti-CD44 Recombinant Antibody (clone IM7) | Block | Rat IgG2b |
NEUT-383CQ | Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC | Block, FC, IP, WB, FuncS | Rat IgG1, κ |
NEUT-384CQ | Rat Anti-CD44 Recombinant Antibody (clone KM81) | IF, IHC-P, FC, Block | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-379CQ | Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG2a |
NEUT-380CQ | Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) | WB, Neut, ELISA, FC, IF, IHC, IP | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0563 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) | FC, IF, IHC-Fr, IHC-P, WB | Rabbit IgG |
MOR-4548 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) | IF, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0019-CN-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); scFv Fragment | FC | Mouse scFv |
HPAB-0154-FY-S(P) | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1); scFv Fragment | Inhib | Humanized scFv |
HPAB-N0328-YC-S(P) | Rat Anti-CD44 Recombinant Antibody (clone 9A4); scFv Fragment | WB, ELISA, IHC-P, IHC-Fr | Rat scFv |
HPAB-1055-FY-F(E) | Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1055-FY-F(E)) | IHC, Inhib, FC | Mouse Fab |
HPAB-1056-FY-F(E) | Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1056-FY-F(E)) | IHC, Inhib, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0154-FY | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1) | Inhib, WB | Humanized IgG1 |
MRO-0306-CN | Rabbit Anti-CD44 Recombinant Antibody (clone CBACN-118) | WB, IHC, FC | Rabbit IgG |
MRO-0307-CN | Mouse Anti-CD44 Recombinant Antibody (clone A7-1) | WB, IHC, FC | Mouse IgM |
HPAB-0047-YJ | Mouse Anti-CD44 Recombinant Antibody (clone HI44a) | WB, IF, FC, FuncS | Mouse IgG2a |
HPAB-0563-WJ | Human Anti-CD44 Recombinant Antibody (clone 1A9) | WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0154-FY-F(E) | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1); Fab Fragment | Inhib | Humanized Fab |
HPAB-N0328-YC-F(E) | Rat Anti-CD44 Recombinant Antibody (clone 9A4); Fab Fragment | WB, ELISA, IHC-P, IHC-Fr | Rat Fab |
HPAB-0141CQ-F(E) | Mouse Anti-CD44 Recombinant Antibody (clone A3D8); Fab Fragment | FC, IHC, WB | Mouse Fab |
HPAB-0047-YJ-F(E) | Mouse Anti-CD44 Recombinant Antibody (clone HI44a); Fab Fragment | WB, IF, FC | Mouse Fab |
HPAB-1173WJ-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1173WJ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-727 | Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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