Anti-Human CD3E Recombinant Antibody (TAB-H52) (CAT#: TAB-H52)
Recombinant Humanized (from rat) antibody to Human CD3E. It is a monoclonal antibody, which is being developed for the treatment of type 1 diabetes and other autoimmune diseases.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line JURKAT
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
Figure 2 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
Specifications
- Host Species
- Rat
- Derivation
- Humanized (from rat)
- Type
- IgG1 - lambda
- Specificity
- CD3E (CD3 epsilon) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, WB
- MW
- 145.1 kDa
- Related Disease
- Psoriasis
Product Property
- Purity
- Purity >95% by SDS-PAGE.
Applications
- Application Notes
- The CD3E antibody has been reported in applications of Neut, Inhib, FC, RT-PCR, IHC.
IHC: Monoclonal anti-human CD3 (2.5 μg/mL) was used as a primary antibody for incubation overnight at 4 °C. After incubation with secondary antibody, rat anti-mouse IgG heavy chain (LO-MG1-13: Abcam ab11585), biotin-labelled rabbit anti-rat IgG (5.0 μg/mL), and HRP-labeled streptavidin (5.0 μg/mL) were applied according to the standard ABC method. Tris-HCl buffer with 0.05% 3.3′-diaminobenzidine (DAB) in 0.03% hydrogen peroxide was used for staining.
Target
- Alternative Names
- otelixizumab;881191-44-2;TRX4;ChAglyCD3;GSK2136525;TRX4;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;
- Gene ID
- 916
- UniProt ID
- P07766
Related Resources
Please refer to Otelixizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Otelixizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2a / G2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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