Anti-Human CD40 ligand Recombinant Antibody (Toralizumab) (CAT#: TAB-876)
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. Toralizumab was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenstrom's macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin's disease).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line JURKAT
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg
Figure 2 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg
Figure 3 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg
Figure 4 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
- CAS
- 252662-47-8
- Generic Name
- toralizumab
- MW
- 148,426 Daltons
- Related Disease
- Systemic lupus erythematosus (SLE)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- toralizumab;252662-47-8;IDEC-131;E6040;IDEC 131;CD40LG;CD40 ligand;HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome);CD40 antigen ligand;CD40L;CD154;gp39;hCD40L;hyper IgM syndrome;T B cell activating molecule;T
- Gene ID
- 959
- UniProt ID
- P29965
Related Resources
Please refer to Toralizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Toralizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Toralizumab"
Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. It was a humanized monoclonal antibody and an immunosuppressive drug.
DrugMonitor™ Anti-Toralizumab Antibody (VS-1224-YC1223)Toralizumab (IDEC 131) was a humanized monoclonal antibody and immunosuppressive drug. The DrugMonitor™ Anti-Toralizumab Antibody (VS-1224-YC1223) is an anti-drug antibody (ADA) against Toralizumab. This drug-based antibody is raised in mice immunized with the Toralizumab. The anti-Toralizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Toralizumab in samples.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1071z | Mouse Anti-CD40LG Recombinant Antibody (clone 18C1) | ELISA, FC, FuncS, ICC, IF | Mouse IgG1 |
| HPAB-0179-YC | Human Anti-CD40LG Recombinant Antibody (HPAB-0179-YC) | ELISA | Human IgG1 |
| HPAB-0880LY | Mouse Anti-CD40LG Recombinant Antibody (HPAB-0880LY) | FC | Mouse IgG1 |
| HPAB-0881LY | Mouse Anti-CD40LG Recombinant Antibody (HPAB-0881LY) | FC | Mouse IgG1 |
| MRO-0304-CN | Rabbit Anti-CD40LG Recombinant Antibody (clone JM11-34) | WB, IF, IHC, FC | Rabbit IgG |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-876, RRID: AB_3112012)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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