Recombinant Humanized (from mouse) antibody to Human CD70. Vorsetuzumab is a monoclonal antibody designed for the treatment of cancer.
Figure 1 Treatment with vorsetuzumab and KWAR23 led to strong inhibition of tumor growth in SRG mice.
Tumor growth in SRG mice treated with PBS (n = 7), vorsetuzumab (n = 3), vorsetuzumab + KWAR23 (n = 5), or bispecific anti-CD70/KWAR23 (n = 6). The color of the stars indicates comparison of the PBS group with the corresponding treatment group. ns, not significant.
Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J. P., George, B. M., ... & Zheng, Y. (2017). Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences, 114(49), E10578-E10585.
Figure 2 In vitro experiments show that KWAR23 only moderately induced macrophage phagocytosis of four different renal carcinoma cell lines (RCC4, RCC10, TK10, and Caki-1) following incubation with the anti-human CD70 antibody vorsetuzumab.
Phagocytosis of four different renal carcinoma cells by human macrophages following treatment with vorsetuzumab, vorsetuzumab + KWAR23, bispecific anti-human CD70/KWAR23, and anti-human CD47 antibody (n = 4). Mean ± SEM is shown. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (unpaired two-tailed Student's t test).
Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J. P., George, B. M., ... & Zheng, Y. (2017). Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences, 114(49), E10578-E10585.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human CD70. Vorsetuzumab is a monoclonal antibody designed for the treatment of cancer.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
TAB-344LC | Human Anti-CD70 Recombinant Antibody (TAB-344LC) | FC, FuncS | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-336LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VLVH) | FC, ELISA | Human antibody |
TAB-337LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (Mb VHVL) | FC, ELISA | Human antibody |
TAB-338LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-5-VH) | FC, ELISA | Human antibody |
TAB-339LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VH-5-VL) | FC, ELISA | Human antibody |
TAB-340LC-F(E) | Anti-Human CD70 Recombinant Antibody Fab Fragment (VL-8-VH) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
HPAB-0097-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0097-LSX) | ELISA, FC, Block, FuncS | Human IgG |
HPAB-0099-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0099-LSX) | ELISA, FC, Block | Human IgG |
HPAB-0100-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0100-LSX) | ELISA, Inhib, ADCC, ADCP, CDC, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0468-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0468-WJ-S(P)) | ELISA | Human scFv |
HPAB-0469-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0469-WJ-S(P)) | ELISA | Human scFv |
HPAB-0470-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0470-WJ-S(P)) | ELISA | Human scFv |
HPAB-0471-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0471-WJ-S(P)) | ELISA | Human scFv |
HPAB-0472-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0472-WJ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP584-YC-F(E) | Mouse Anti-CD70 Recombinant Antibody (clone m1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Mouse Fab |
HPAB-AP585-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone c1F6); Fab Fragment | FC, ADCC, CDC, FuncS | Chimeric (mouse/human) Fab |
HPAB-AP586-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
HPAB-AP587-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
HPAB-AP588-YC-F(E) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); Fab Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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