This product is a monoclonal antibody that recognizes an epitope within the MUC1 tandem repeat array. The H23 can detect MUC1/REP and MUC1/SEC. This antibody can inhibit the proliferation and growth of tumor cells as well as inducing cell death in cancer cells inducing epithelial, colon, lung, breast and ovarian tumor cells or other cells that express MUC1 proteins.
Figure 1 Binding of MUC1-expressing cells and tumor sections by humanized H23.
Flow-cytometry analysis. Mouse DA3 transfected cells, expressing the MUC1 gene were incubated with 100 μg/ml HumH23 MBP-scFv (I), 100 μg/ml MuH23 MBP-scFv (II), 10 μg/ml of H23 Mab (III), 100 μg/ml anti-fluorescein MBP-4-4-20(Fv) (IV), for 2 h at room temperature. The cells that were incubated with MBP-scFvs were stained with a mouse anti-MBP Mab followed by FITC-labeled goat anti-mouse IgG antibodies. Cells that were incubated with H23 Mab were stained with FITC-labeled goat anti-mouse IgG antibodies. As control, cells were stained with FITC-labeled secondary antibodies alone.
Mazor, Y., Keydar, I., & Benhar, I. (2005). Humanization and epitope mapping of the H23 anti-MUC1 monoclonal antibody reveals a dual epitope specificity. Molecular immunology, 42(1), 55-69.
Figure 2 Binding of MUC1-expressing cells and tumor sections by humanized H23.
Immunohistochemical staining of breast cancer cells and tumor sections. Paraffin-embedded T47D breast cancer cells (I–III with 63× magnification) and breast cancer tissue samples (IV–VI with 40× magnification) were stained with 100 μg/ml HumH23 MBP-scFv (I, IV), anti-fluorescein MBP-4-4-20(Fv) (II, V) or 10 μg/ml of H23 Mab (III,VI). MBP-scFvs were detected with anti-MBP Mab followed by HRP-conjugated goat anti-mouse antibodies that were also used to detect staining by the H23 Mab.
Mazor, Y., Keydar, I., & Benhar, I. (2005). Humanization and epitope mapping of the H23 anti-MUC1 monoclonal antibody reveals a dual epitope specificity. Molecular immunology, 42(1), 55-69.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-765 | Mouse Anti-MUC1 Recombinant Antibody (clone Nacolomab); Fab Fragment | FC, IP, ELISA, Neut, FuncS, IF, ICC | Mouse Fab (IgG1, κ) |
TAB-0388CL | Mouse Anti-Human MUC1 Recombinant Antibody | WB, IHC | |
TAB-0388CL-S(P) | Mouse Anti-Human MUC1 Recombinant Antibody scFv Fragment | WB, IHC | |
TAB-0388CL-F(E) | Mouse Anti-Human MUC1 Recombinant Antibody Fab Fragment | WB, IHC | |
PABX-183-S (P) | Recombinant Mouse Anti-MUC1 Antibody scFv Fragment (CTM01) | Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L036E | anti-MUC1 immunotoxin C242 (Fab)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L064E | anti-MUC1 immunotoxin H23 (scFv)-PE | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-412MZ | Human Anti-MUC1 Recombinant Antibody (TAB-412MZ) | ELISA | Chimeric (mouse/human) IgG |
TAB-412MZ-S(P) | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P)) | ELISA | Mouse scFv |
TAB-412MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-413MZ | Human Anti-MUC1 Recombinant Antibody (TAB-413MZ) | ELISA | Humanized IgG |
TAB-425MZ | Anti-Human MUC1 Recombinant Antibody (huDMB5F3) | ELISA, FC, FuncS, ICC | Humanized antibody |
TAB-430MZ | Anti-Human MUC1 Recombinant Antibody (BLC595) | ELISA, FC | Humanized antibody |
TAB-413MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-413MZ-F(E)) | ELISA | Humanized Fab |
TAB-425MZ-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (huDMB5F3) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-431MZ-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1) | ELISA, WB, FC, IHC | Human antibody |
TAB-432MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-432MZ-F(E)) | ELISA, FC | Human Fab |
TAB-433MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-433MZ-F(E)) | ELISA, FC | Human Fab |
TAB-434MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-434MZ-F(E)) | ELISA, FC | Human Fab |
PABX-143 | Recombinant Human Anti-MUC1 Antibody (CTM01) | WB, ELISA, FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-012LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
Gly-120LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-012LC-1 | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-109LC | Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-121LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
Gly-122LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
Gly-123LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
Gly-124LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0379MZ | Chicken Anti-MUC1 Polyclonal IgY | IHC, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2320 | Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) | IHC-P, IHC-Fr | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0838LC | Recombinant Mouse Anti-Human MUC1 Antibody (SM3) | ELISA | IgG1 |
EPAF-0581CQ | Recombinant Mouse Anti-Human MUC1 Antibody (B27.29) | Neut, FC | IgG1 |
EPAF-0583CQ | Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549) | Neut, FC | IgG1 |
EPAF-0584CQ | Recombinant Mouse Anti-Human MUC1 Antibody (DF3) | Neut, FC | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0091-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0091-YC-F(E)) | ELISA, Neut | Mouse Fab |
HPAB-0094-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody (clone 12D10); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-0670-CN-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0670-CN-F(E)) | FC | Human Fab |
PFBC-399 | Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5); Fab Fragment | ELISA, FC, FuncS | Mouse Fab |
PFBC-400 | Mouse Anti-MUC1 Recombinant Antibody (clone SM3); Fab Fragment | FC, IHC-Fr, IF, ELISA, IHC-P | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0670-CN-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0670-CN-S(P)) | FC | Human scFv |
HPAB-0495-FY-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0495-FY-S(P)) | ELISA | Human scFv |
HPAB-0496-FY-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0496-FY-S(P)) | ELISA | Human scFv |
HPAB-J0212-YC-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone BW835); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-1162WJ-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone C4); scFv Fragment | ELISA, ICC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0872LY | Mouse Anti-MUC1 Recombinant Antibody (HPAB-0872LY) | ELISA, WB, FC | Mouse IgG1 |
HPAB-0873LY | Human Anti-MUC1 Recombinant Antibody (HPAB-0873LY) | ELISA, WB, FC | Humanized IgG1 |
HPAB-0874LY | Mouse Anti-MUC1 Recombinant Antibody (HPAB-0874LY) | ELISA, WB, FC | Mouse IgG1 |
HPAB-0875LY | Human Anti-MUC1 Recombinant Antibody (HPAB-0875LY) | ELISA, WB, FC | Humanized IgG1 |
MRO-1039-CN | Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (CBACN-385) | WB, IF, IHC, IP, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H56 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-H65 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-026ML | Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-166 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
AFC-TAB-H77 | Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) | ELISA, FC, IP, FuncS, IF | IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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