Recombinant Human Antibody (bH1) is capable of binding to VEGFA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VEGFA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti- VEGFA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibits both HER2- and VEGF-mediated cell proliferation in vitro and tumor progression in mouse models.
Figure 1 Inhibition of VEGF and HER2 function in vitro and in vivo.
bH1 and the affinity improved variants bH1-81 and bH1-44 as IgGs inhibit VEGF-stimulated proliferation of HUVECs in a dose-dependent manner. Herceptin and bevacizumab (anti-VEGF) were used as controls. Error bars represent the average deviation of triplicates (n = 3).
Bostrom, J., Yu, S. F., Kan, D., Appleton, B. A., Lee, C. V., Billeci, K., ... & Fuh, G. (2009). Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science, 323(5921), 1610-1614.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-012-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (Ranibizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-284CQ | Human Anti-VEGFA Recombinant Antibody (TAB-284CQ) | WB | Human antibody |
TAB-284CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-284CQ-F(E)) | ELISA | Human Fab |
TAB-304CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1) | ELISA, WB | Human antibody |
TAB-305CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1-32) | ELISA, WB | Human antibody |
TAB-465CQ | Anti-Human VEGFA Recombinant Antibody (Varisacumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2179MZ | Recombinant Mouse Anti-Human VEGFA Antibody (clone 7C8) | IP, WB | Mouse antibody |
HPAB-0151-FY | Human Anti-VEGFA Recombinant Antibody (clone rhVVH) | WB, ELISA, Inhib | Human IgM |
FN-019CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 3(6D3)) | ELISA, FuncS, WB | Mouse IgG1 |
HPAB-M0242-YC | Human Anti-VEGFA Recombinant Antibody (clone B5E3) | ELISA | Humanized IgG |
HPAB-M0243-YC | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb) | ELISA, Block, Inhib | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2255CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL198) | Neut, WB | Mouse IgG1 |
NEUT-2256CQ | Rat Anti-Vegfa Recombinant Antibody (clone 2G11-2A05) | WB, Neut, ELISA, IHC, FuncS | Rat IgG2a, κ |
NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MD-ZBF-YC024 | Camelid Anti-VEGFA Recombinant Single Domain Antibody (MD-ZBF-YC024) | ELlSA | Camelid VHH |
HPAB-N0310-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (HPAB-N0310-YC-VHNAR) | ELISA, FC, WB | Shark vNAR |
HPAB-N0311-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (HPAB-N0311-YC-VHNAR) | ELISA, FC, WB | Shark vNAR |
HPAB-0646-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0646-YJ-VHH) | ELISA, Inhib | Camelid VHH |
HPAB-0647-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0647-YJ-VHH) | ELISA, Inhib | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0372-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0372-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-M0373-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0373-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-M0374-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0374-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-0336-YJ-F(E) | Human Anti-VEGFA Recombinant Antibody (clone BAT-1706); Fab Fragment | FuncS | Humanized Fab |
HPAB-0152-WJ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-0152-WJ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0715-FY-F(E) | Mouse Anti-VEGFA Recombinant Antibody (clone AB014); scFv Fragment | ELISA | Mouse scFv |
HPAB-0950-FY-F(E) | Camelid Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-0950-FY-F(E)) | Inhib | Camelid Fab |
HPAB-0114-WJ-S(P) | Human Anti-VEGFA Recombinant Antibody (clone FD006); scFv Fragment | ELISA | Humanized scFv |
HPAB-0938WJ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-0938WJ-S(P)) | ELISA | Human scFv |
HPAB-2046-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone C1039); scFv Fragment | IA | Human scFv |
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