IGF1-DT immunotoxin (CAT#: AGTO-L024D)
This immunotoxin was achieved by conjugating/fusing the IGF1 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of breast, prostate, and lung cancers.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
Figure 6 Heart muscle
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- IGF1-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Breast, prostate, and lung cancers
Target
- Alternative Names
- IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389
- Gene ID
- 3480
- UniProt ID
- P08069
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Type I Diabetes Mellitus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IGF1R"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-091 | Recombinant Anti-human IGF1R VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-096ZJ | Anti-Human IGF-1R Therapeutic Single Domain Antibody (TAB-096ZJ) | ELISA, IHC, IF, WB | Single domain antibody |
| HPAB-1545-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1545-FY) | WB, ELISA | Llama VHH |
| HPAB-1546-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1546-FY) | WB, ELISA | Llama VHH |
| HPAB-1547-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1547-FY) | WB, ELISA | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078 | Anti-Human IGF1 Receptor Recombinant Antibody (Cixutumumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - lambda |
| TAB-209 | Anti-Human IGF1 Receptor Recombinant Antibody (Robatumumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-052ZJ | Anti-Human IGF-1R Recombinant Antibody (18) | IHC, ELISA, FC, IF, IP | Human antibody |
| TAB-053ZJ | Anti-Human IGF-1R Recombinant Antibody (IR3) | ELISA, FC, WB | Human antibody |
| TAB-054ZJ | Anti-Human IGF-1R Recombinant Antibody (IR10) | ELISA, FC, WB | Human antibody |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L024E | IGF1-PE immunotoxin | Cytotoxicity assay, Functional assay |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-371CL | Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL) | ELISA | ADCC enhanced antibody |
| AFC-TAB-199 | Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, κ |
| AFC-TAB-736 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Dalotuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-078 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Cixutumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-232 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Figitumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-035ZJ-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-035ZJ-S(P)) | ELISA, FC | Humanized scFv |
| TAB-036ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-037ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (H1L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-038ZJ-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-038ZJ-S(P)) | ELISA, FC, Inhib, IP | Humanized scFv |
| TAB-051ZJ-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-051ZJ-S(P)) | ELISA, IHC, IF, WB | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-009ZJ-F(E)) | ELISA, FC | Mouse Fab |
| TAB-010ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11) | ELISA, Neut, FC, IHC | |
| TAB-011ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-011ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
| TAB-012ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-012ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
| TAB-014ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-014ZJ-F(E)) | ELISA, FC, Inhib, IP | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| TAB-085ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c) | ELISA, Neut, FC, IHC | Chimeric antibody (mouse/human) |
| TAB-086ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E)) | ELISA, FC, Inhib, IP | Chimeric (mouse/human) Fab |
| TAB-087ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
| TAB-093ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch9E11) | ELISA | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0103MZ | Chicken Anti-CD221 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
| NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
| NEUT-1082CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL080) | Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
| NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
| NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
| NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
| MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
| MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0084-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0084-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0085-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0085-YC-F(E)) | Block, FuncS, FC, ELISA | Human Fab |
| HPAB-0210CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment | ELISA, FC, Neut | Human Fab |
| HPAB-0211CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 1H3); Fab Fragment | ELISA, FC, Neut | Human Fab |
| HPAB-0212CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 11A4); Fab Fragment | ELISA, FC, Block | Human Fab |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
| NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0210CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-0211CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 1H3); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-1277WJ-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1945-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1945-FY-S(P)) | Inhib | Human scFv |
| HPAB-2063-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-2063-FY-S(P)) | IA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1441LY | Human Anti-IGF1R Recombinant Antibody (HPAB-1441LY) | ELISA, IHC | Humanized IgG |
| HPAB-1442LY | Human Anti-IGF1R Recombinant Antibody (HPAB-1442LY) | ELISA, IHC | Humanized IgG |
| HPAB-0069-YJ | Human Anti-IGF1R Recombinant Antibody (HPAB-0069-YJ) | ELISA, Block, FC, FuncS | Human IgG2, κ |
| HPAB-1732-FY | Human Anti-IGF1R Recombinant Antibody (HPAB-1732-FY) | Block, Inhib | Human IgG1 |
| VS3-QX581 | Mouse Anti-IGF1R Recombinant Antibody (clone 3G5C1) | WB, IHC, ICC, FC, ELISA | Mouse IgG2a |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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