This HER3 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=0.7 nM) for HER3 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H47 | Anti-Human ERBB3 Recombinant Antibody (Lumretuzumab) | ELISA, Inhib | Human IgG1, κ |
HPAB-0286-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153) | ELISA, FuncS, FC | Mouse IgG |
HPAB-0287-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104) | ELISA, FuncS, FC | Mouse IgG |
HPAB-0288-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126) | ELISA, FuncS, FC | Mouse IgG |
HPAB-0289-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511) | ELISA, FuncS, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0508CL | Anti-Human ERBB3 Recombinant Antibody (1A5) | ELISA, FC, Inhib, FuncS | |
TAB-0509CL | Anti-Human ERBB3 Recombinant Antibody (3D4) | Inhib, FC | |
TAB-0508CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (1A5) | ELISA, Inhib, FuncS | |
TAB-0509CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (3D4) | ELISA, Inhib, FuncS | |
TAB-060CT-S(P) | Rabbit Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-060CT-S(P)) | Inhib, ELISA | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0046CL-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0046CL-S(P)) | ELISA, FuncS, Inhib, FC | Human scFv |
TAB-0047CL-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0047CL-S(P)) | ELISA, FuncS, Inhib, FC | Human scFv |
TAB-065CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) | ELISA, FC | Human Fab |
TAB-066CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) | ELISA, Inhibion, FC | Human Fab |
TAB-422CQ | Anti-Human ERBB3 Recombinant Antibody (Elgemtumab) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-057CT | Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) | Inhibion, ELISA | Humanized antibody |
TAB-058CT | Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) | ELISA, Inhib, Cty, IHC, WB, FC | Human IgG1, κ |
TAB-059CT | Anti-Human HER3 Recombinant Antibody (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
TAB-057CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-057CT-F(E)) | Inhibion, ELISA | Humanized Fab |
TAB-058CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-058CT-F(E)) | WB, ELISA, Inhib | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0171-WJ-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0171-WJ-F(E)) | ELISA | Human Fab |
HPAB-0200-WJ-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 205.10.1); Fab Fragment | ELISA, WB | Mouse Fab |
HPAB-M0305-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 11G01); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-M0306-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12A07); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-M0307-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 18H02); Fab Fragment | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0608-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0608-WJ-S(P)) | ELISA, IHC | Humanized scFv |
HPAB-0609-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0609-WJ-S(P)) | ELISA, IHC | Humanized scFv |
HPAB-1696-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1696-FY-F(E)) | ELISA | Human Fab |
FAMAB-0047JF-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBS-0069 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) | ELISA, Block, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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