This IL-6 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=500 pM) for IL-6 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0022CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0022CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
TAB-0023CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0023CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
TAB-0024CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0024CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
TAB-0025CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0025CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
TAB-673LC | Anti-human IL6 Recombinant Antibody | ELISA, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
TAB-0172CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0172CL-S(P)) | ELISA, Block, In vivo | Human scFv |
TAB-0173CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0173CL-S(P)) | ELISA, Block, In vivo | Human scFv |
TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0026CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
TAB-670LC-S(P) | Anti-human IL6 scFv Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0174CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0174CL-F(E)) | ELISA, Block, In vivo | Human Fab |
TAB-0175CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0175CL-F(E)) | ELISA, Block, In vivo | Human Fab |
TAB-0176CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0176CL-F(E)) | ELISA, Block, In vivo | Human Fab |
TAB-681LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-681LC-F(E)) | ELISA | Human Fab |
TAB-682LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-682LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1465CQ | Mouse Anti-IL6 Recombinant Antibody (VMC201) | Neut, WB, IHC | Mouse IgG2 |
NEUT-1466CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL224) | IHC, ELISA, Neut | Mouse IgG1 |
NEUT-1467CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL260), FITC | FC, Neut | Mouse IgG1 |
NEUT-1468CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL414) | WB, IHC, ELISA, Neut | Mouse IgG1 |
NEUT-1469CQ | Rat Anti-IL6 Recombinant Antibody (clone CBL888) | ELISA, FC, IF, IP, Neut, WB | Rat IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0017-YC-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0017-YC-S(P)) | ELISA, Block | Human scFv |
HPAB-0674-CN-S(P) | Human Anti-IL6 Recombinant Antibody (clone 9C8-N68T-T83S); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0876-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0876-FY-F(E)) | ELISA | Human Fab |
HPAB-0877-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0877-FY-F(E)) | ELISA | Human Fab |
HPAB-S0083-YC-S(P) | Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0083-YC-S(P)) | ELISA, Block | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0674-CN | Human Anti-IL6 Recombinant Antibody (clone 9C8-N68T-T83S) | ELISA, FC | Human IgG2 |
HPAB-0164-YJ | Mouse Anti-IL6 Recombinant Antibody (clone 6yl-9) | ELISA, WB, Inhib, Neut | Mouse IgG1, κ |
FN-242CQ | Rat Anti-Il6 Recombinant Antibody (clone MP5-32C11) | FuncS | Rat IgG2a, κ |
HPAB-0876-FY | Human Anti-IL6 Recombinant Antibody (HPAB-0876-FY) | ELISA | Human IgG |
HPAB-0877-FY | Human Anti-IL6 Recombinant Antibody (HPAB-0877-FY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0876-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0876-FY-S(P)) | ELISA | Human scFv |
HPAB-0877-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0877-FY-S(P)) | ELISA | Human scFv |
HPAB-1250-FY-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1250-FY-S(P)) | ELISA | Mouse scFv |
HPAB-1251-FY-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1251-FY-S(P)) | ELISA | Mouse scFv |
HPAB-1252-FY-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1252-FY-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0166-YC) | ELISA | Camelid VHH |
HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0167-YC) | ELISA | Camelid VHH |
HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0168-YC) | ELISA, Inhib | Camelid VHH |
HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0169-YC) | ELISA, Inhib | Camelid VHH |
HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (HPAB-S0170-YC) | ELISA, Inhib | Camelid VHH |
There are currently no Customer reviews or questions for SZA-L232. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.