This product is a recombinant humanized antibody that recognizes human APP. It may function in treating and/or preventing amyloid-beta associated diseases such as Alzheimer's disease.
Figure 1 A qualitative assessment of the interactions between murine 5E3, cdr5E3, hu5E3 and rehu5E3 constructs and the cSNK:BSA conjugate using biolayer inter ferometry.
Key to the sensor traces: A4, D4, and E4: three clonal isolates of murine 5E3; B4: Empty; C4: Irrelevant Ab; F4: cdr5E3 (IgG1); G4: hu5E3 (IgG1); and H4: rehu5E3 (IgG1).
Figure 2 A graph showing the immunoreactivity of murine 5E3, chimeric 5E3 IgG1, and humanized 5E3 IgG1 constructs (hu5E3, rehu5E3, and cdr5E3) to captured cSNK by ELISA.
Figure 3 The results of Western immunoblots with murine and humanized 5E3 constructs purified from CHOK1SV cells.
Blots were probed with either murine 5E3 (m5E3), or humanized 5E3 IgG1, IgG2 and IgG4 mAbs against the cSNK epitope conjugated to BSA (BSA-cSNK). These blots were only positive for the cSNK epitope and did not bind the negative controls (unconjugated BSA or Ovalbumin).
Figure 4 Western immunoblot analysis of non-reduced 5 ug of BSA, cSNK conjugated to BSA (BSA-cSNK) and ovalbumin control (OVA) probed with purified hu5E3 IgG1.
Figure 5 Western immunoblot analysis of non-reduced purified hu5E3 IgG1 probed with anti-human IgG.
Figure 6 Binding of hu5E3 IgG1, IgG2, and IgG4 isotypes to Amyloid beta oligomers (Αβ oligomers) prepared from recombinant Αβ peptides by biacore.
Figure 7 Binding of hu5E3-IgG1 to Amyloid beta oligomers (Αβ oligomers) prepared from recombinant Αβ peptides by biacore.
Figure 8 The immunoreactivity of humanized 5E3 IgG1 and Δ5Ε3 IgG1 constructs to captured cSNK by ELISA.
Figure 9 The immunoreactivity of humanized 5E3 IgG1 and Δ5Ε3 IgG1 constructs to captured ccSNK by ELISA.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-225 | Anti-Human Abeta Recombinant Antibody (Bapineuzumab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
TAB-0828CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E)) | ELISA | Humanized Fab |
TAB-0829CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E)) | ELISA | Humanized Fab |
TAB-0830CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E)) | ELISA | Humanized Fab |
TAB-0831CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0831CLV-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0343CL | Human Anti-APP Recombinant Antibody (TAB-0343CL) | ELISA, Inhib | Human IgG |
TAB-0801CLV | Anti-Human APP Recombinant Antibody (3H3) | IHC, FuncS | Fully human antibody |
TAB-0815CLV | Human Anti-APP Recombinant Antibody (TAB-0815CLV) | ELISA | Human IgG |
TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH) | ELISA, IHC | Single domain antibody |
TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0022CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0023CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0023CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-254CQ | Human Anti-APP Recombinant Antibody (TAB-254CQ) | ELISA | Chimeric (mouse/human) IgG1 |
TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0802CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0792CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0792CLV-S(P)) | ELISA | Mouse scFv |
TAB-0808CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0808CLV-S(P)) | ELISA | Mouse scFv |
TAB-0827CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0827CLV-S(P)) | ELISA | Mouse scFv |
TAB-0838CLV-S(P) | Mouse Anti-Abeta protofibril Recombinant Antibody; scFv Fragment (TAB-0838CLV-S(P)) | ELISA | Mouse scFv |
TAB-0839CLV-S(P) | Mouse Anti-Abeta protofibril Recombinant Antibody; scFv Fragment (TAB-0839CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0176-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0176-FY) | AG | Mouse IgG1, κ |
HPAB-0116CQ | Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) | ELISA, WB, IP, FuncS | Mouse IgG1, κ |
HPAB-0117CQ | Human Anti-APP Recombinant Antibody (HPAB-0117CQ) | ELISA, WB, IP, FuncS | Human IgG1, κ |
HPAB-0118CQ | Human Anti-APP Recombinant Antibody (clone Fv1E4) | ELISA, Inhib | Human IgG |
HPAB-0119CQ | Human Anti-APP Recombinant Antibody (clone h12A11v1) | ELISA, CFC, FuncS | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-394 | Mouse Anti-APP Recombinant Antibody (clone c#6); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
PSBC-395 | Mouse Anti-APP Recombinant Antibody (clone c#24); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
HPAB-0986-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 6F6); scFv Fragment | ELISA | Mouse scFv |
HPAB-0988-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2C1); scFv Fragment | ELISA | Mouse scFv |
HPAB-0989-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2E11); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0008-YJ-F(E) | Mouse Anti-APP Recombinant Antibody (clone 508F); Fab Fragment | ELISA | Mouse Fab |
HPAB-0732-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0732-FY-S(P)) | DB, ELISA | Mouse scFv |
HPAB-0733-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0733-FY-S(P)) | DB, ELISA | Mouse scFv |
HPAB-0735-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H2L1); Fab Fragment | ELISA, FC, WB | Humanized Fab |
HPAB-0736-FY-S(P) | Human Anti-APP Recombinant Antibody (clone H51L21); Fab Fragment | ELISA, FC, WB | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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