Rabbit Anti-HSP90AA1 Recombinant Antibody (clone R02-6B7) (CAT#: VS3-XY3387)
This is a recombinant rabbit antibody targeting the human HSP90AA1 (Heat shock protein 90 alpha family class A member 1), which engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes. The antibody also has cross-reactivity against mouse and rat HSP90AA1. It has been reported for use in Western Blot, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/if_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/ihc_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/673_C12_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/673_C12_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/667_C12_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/667_C12_1_blue_red_green.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/5779_A_5_6.jpg
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/5779_A_5_6.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat HSP90AA1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-6B7
- Applications
- WB, ICC, IF, IP
- Related Disease
- Candidiasis; Herpes Simplex
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
- Gene ID
- 3320
- UniProt ID
- P07900
- Long Name
- Heat shock protein 90 alpha family class A member 1
- Cellular Localization
- Nucleus, Cytoplasm, Melanosome, Cell membrane, Mitochondrion
- Post Translation Modifications
- Glycosylation at Asn397 (NX_P07900 [NX_P07900-1])
Ubiquitination at Lys58, Lys84, Lys224, Lys314, Lys419, Lys436, Lys443, Lys446, Lys478, Lys489, Lys499, Lys513, and Lys632 (NX_P07900 [NX_P07900-1])
Modification sites at PhosphoSitePlus (P07900)
Glycosylation from GlyConnect HS90A_HUMAN (1301)
Glycosylation from GlyGen (P07900) 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011535020.1; XP_054231954.1
- Function
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity.
This cycle probably induces conformational changes in the client proteins, thereby causing their activation.
Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HSP90AA1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1333z | Mouse Anti-HSP90AA1 Recombinant Antibody (clone 22C8) | ELISA, FC, IHC, WB | Mouse IgG |
| MRO-0780-CN | Mouse Anti-HSP90AA1 Recombinant Antibody (clone A10-A5-D2) | WB, IF, IHC, FC | Mouse IgG1 |
| MRO-0781-CN | Rabbit Anti-HSP90AA1 Recombinant Antibody (clone CBACN-292) | WB, IF, IHC | Rabbit IgG |
| VS3-QX545 | Mouse Anti-HSP90AA1 Recombinant Antibody (clone 6H7-A3-2G6) | WB | Mouse IgG1 |
| VS3-QX546 | Mouse Anti-HSP90AA1 Recombinant Antibody (clone 5D6-2G8-6D5) | WB, IHC | Mouse IgG1 |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0266MZ | Chicken Anti-HSPN Polyclonal IgY | WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1689 | Rabbit Anti-HSP90AA1 Recombinant Antibody (clone DS1689AB) | WB, IHC-P, ICC, IF | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF489 | A*29:02/Human HSP90 alpha (KEKYIDQEEL) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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