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Mouse Anti-HSPB1 Recombinant Antibody (VS3-CJ377) (CAT#: VS3-CJ377)

This product is a mouse antibody that recognizes HSPB1.

See more Engineered Antibody products for HSPB1
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Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47330/if_selected.jpg
Normal Tissue
Figure 2 Esophagus
Figure 2 Esophagus
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4439/17421_B_4_1_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47331/104843_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47331/104843_A_7_5.jpg
Figure 5 High expression in vagina
Figure 5 High expression in vagina
(Squamous epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47331/104843_B_2_2.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTCEpi, MCF7)
Figure 6 RNA cell line category: Cell line enhanced (hTCEpi, MCF7)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106211-HSPB1

Specifications

  • Immunogen
  • Recombinant protein corresponding to human HSP27
  • Host Species
  • Mouse
  • Specificity
  • Human HSPB1
  • Species Reactivity
  • Human
  • Applications
  • WB, IHC
  • Conjugate
  • Unconjugated

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 30% Glycerol, 0.87% NaCl, 0.42% Potassium phosphate, pH7.3.
  • Preservative
  • 0.01% sodium azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot (1:1000-1:2000), Immunohistochemistry (1:50-1:200).

Target

  • Alternative Names
  • CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
  • Sequence Similarities
  • Belongs to the small heat shock protein (HSP20) family.
  • Cellular Localization
  • Cytoplasm, Cytoskeleton, Nucleus
  • Post Translation Modifications
  • Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890).
    Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925).
  • Function
  • Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975).
    Plays a role in stress resistance and actin organization (PubMed:19166925).
    Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Rabbit Monoclonal Antibody

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MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC2094 PE-B*07:02/Human HSPB1 (APAYSRAL) MHC Tetramer FCM
MHC-LC2095 APC-B*07:02/Human HSPB1 (APAYSRAL) MHC Tetramer FCM

Recombinant Antibody

CAT Product Name Application Type
ZG-0751J Rabbit Anti-HSPB1 Recombinant Antibody (clone 2E8) ELISA, WB, IHC Rabbit IgG
ZG-0752J Rabbit Anti-HSPB1 Recombinant Antibody (clone 2D8) ELISA, WB, IHC Rabbit IgG
ZG-0753J Rabbit Anti-HSPB1 Recombinant Antibody (clone 10C11) ELISA, WB, IHC, IF, FC, IP Rabbit IgG
VS3-WK1361 Mouse Anti-HSPB1 Antibody (clone Mix-mA) WB, IHC-P Mouse IgG
VS3-WK1433 Mouse Anti-HSPB1 Recombinant Antibody (VS3-WK1433) WB Mouse IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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