Mouse Anti-IL21 Recombinant Antibody (clone 3E11) (CAT#: HPAB-0657-CN)
This is a monoclonal antibody which binds and neutralizes the activity of IL-21 in particular human IL-21. The mAb 3E11 can be used to treat certain IL-21 responsive disorders, for example, certain inflammatory bowel diseases or psoriasis.
Specific Inquiry
FC
Figure 1 IL-21 induces plasma cell differentiation.
Data are representative of results from three similar experiments.
Ettinger, R., Sims, G. P., Fairhurst, A. M., Robbins, R., da Silva, Y. S., Spolski, R., ... & Lipsky, P. E. (2005). IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. The Journal of Immunology, 175(12), 7867-7879.
WB
Figure 2 IL-21 alters the antiapoptotic profile induced by CD40L by downregulating Bcl-XL and induces proliferation through Jak-STAT3.
CLL cells, cultured with CD40L-expressing fibroblasts in the absence or presence of IL-21 for 16 hours.
Pascutti, M. F., Jak, M., Tromp, J. M., Derks, I. A., Remmerswaal, E. B., Thijssen, R., ... & van Lier, R. A. (2013). IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood, The Journal of the American Society of Hematology, 122(17), 3010-3019.
IHC
Figure 3 IL-21 expression in lymph nodes from CLL patients.
IL-21 expression was analyzed in 2 paraffin-embedded CLL LN samples by IHC.
Pascutti, M. F., Jak, M., Tromp, J. M., Derks, I. A., Remmerswaal, E. B., Thijssen, R., ... & van Lier, R. A. (2013). IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood, The Journal of the American Society of Hematology, 122(17), 3010-3019.
Specifications
- Immunogen
- Peptide GM2 comprises the following sequence NVS IKK LKR KPP STN corresponding to amino acids 97-1 11 of human IL-21 sequence
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human IL21
- Species Reactivity
- Human
- Clone
- 3E11
- Applications
- WB, FC, IHC
- Related Disease
- Chronic inflammatory bowel diseases (IBD), celiac disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL21 antibody has been reported in applications of Western Blot, Immunohistochemistry, Flow Cytometry.
Target
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1131z | Mouse Anti-IL21 Recombinant Antibody (clone 38D2) | WB, ELISA, FC, ICC, IHC, IP | Mouse IgG2a |
| HPAB-0287-FY | Human Anti-IL21 Recombinant Antibody (clone mAb14) | Inhib, Neut | Human IgG4, κ |
| HPAB-M0538-YC | Mouse Anti-IL21 Recombinant Antibody (HPAB-M0538-YC) | ELISA | Mouse IgG |
| HPAB-M0539-YC | Mouse Anti-IL21 Recombinant Antibody (HPAB-M0539-YC) | ELISA | Mouse IgG |
| HPAB-M0540-YC | Mouse Anti-IL21 Recombinant Antibody (HPAB-M0540-YC) | ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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