Rabbit Anti-PVR Recombinant Antibody (clone R01-8A1) (CAT#: VS3-FY2066)
The anti-Poliovirus receptor antibody detected positive in western blot analysis of poliovirus receptor/PVR in Hela, A549, U2OS lysates. The recombinant monoclonal antibody exhibits selective binding to human PVR.
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WB
Figure 1 Anti-PVR Antibody (VS3-FY2066) in WB.
The Poliovirus Receptor/PVR expression in Hela, A549, U2OS lysates were detected using the anti-Poliovirus Receptor by western blot assay.
Specifications
- Immunogen
- Recombinant human poliovirus receptor/PVR protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PVR
- Species Reactivity
- Human
- Clone
- R01-8A1
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 45 kDa, while the observed molecular weight stands at 60-80 kDa.
- Related Disease
- Poliomyelitis and Paralytic Poliomyelitis
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155
- Gene ID
- 5817
- UniProt ID
- P15151
- Sequence Similarities
- Belongs to the nectin family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- N-glycosylated.
N-glycan at Asn-120: Hex5HexNAc4.
(P15151-PVR_HUMAN)
Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation.
Interaction with TIGIT is required for Phosphorylation.
(P15151-PVR_HUMAN)
Glycosylation at Asn105, Asn120, Asn188, Asn218, Asn237, Asn278, Asn307, and Asn313 (NX_P15151 [NX_P15151-1])
Modification sites at PhosphoSitePlus (P15151)
Glycosylation from GlyConnect PVR_HUMAN (782)
Glycosylation from GlyGen (P15151) 13 sites, 2 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001129240.1; NP_001129241.1; NP_001129242.2; NP_006496.4
- Function
- Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PVR"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3400z | Mouse Anti-PVR Recombinant Antibody (clone 35G12) | WB, FC, ICC, IF | Mouse IgG1 |
| MOB-0791MZ | Recombinant Mouse Anti-Human PVR Antibody (clone E282) | FC, ICC/IF | Mouse antibody |
| FN-074CQ | Recombinant Mouse Anti-PVR Antibody (4.24) | FC, FuncS | Mouse IgG2a |
| VS3-FY1229 | Recombinant Rabbit Anti-PVR Antibody (clone R04-2C7) | WB, IHC-P | Rabbit IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1899CQ | Recombinant Mouse Anti-PVR Antibody (D171) | BL, FC, ICC/IF | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2945 | Hi-Affi™ Recombinant Rabbit Anti-Pvr Monoclonal Antibody (DS2945AB) | ELISA, WB | IgG |
| MOR-4381 | Hi-Affi™ Recombinant Rabbit Anti-PVR Monoclonal Antibody (SI472DS) | WB, ELISA, IP | IgG |
| MOR-4382 | Hi-Affi™ Recombinant Rabbit Anti-PVR Monoclonal Antibody (SI473DS) | ICC/IF, IF, FC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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