Mouse Anti-TIMP1 Recombinant Antibody (VS3-CJ225) (CAT#: VS3-CJ225)

This product is a mouse antibody that recognizes TIMP1.

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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • KLH-conjugated synthetic peptide encompassing a sequence within human TIMP1
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human TIMP1
  • Species Reactivity
  • Human
  • Applications
  • IHC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Immunogen affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 0.2% BSA, PBS.
  • Preservative
  • 0.01% sodium azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • This antibody has been tested for use in Immunohistochemistry (1:100-1:300).

Target

  • Alternative Names
  • CLGI; TIMP; Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1; EPO; HCI
  • Sequence Similarities
  • Belongs to the protease inhibitor I35 (TIMP) family.
  • Cellular Localization
  • Secreted
  • Post Translation Modifications
  • The activity of TIMP1 is dependent on the presence of disulfide bonds.
    N-glycosylated.
  • Function
  • Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Recommended Products

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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