Rab Proteins
Representative Targets of Rab Proteins Full List of Targets of Rab Proteins Tested Data-Supported Products for Targeting Rab Proteins
Rab proteins constitute a large family of small GTPases that play crucial roles in regulating vesicular transport and membrane trafficking within eukaryotic cells. These proteins are key orchestrators of intracellular trafficking, ensuring the accurate delivery of cargo within the cell, from the uptake of molecules at the cell membrane to their transport to specific destinations such as lysosomes, endosomes, the Golgi apparatus, and the plasma membrane. Rab proteins function as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state, with their activity regulated by specific guanine nucleotide exchange factors (GEFs) that facilitate the exchange of GDP for GTP, and GTPase-activating proteins (GAPs) that accelerate the hydrolysis of GTP to GDP.
Each Rab protein is typically associated with specific compartments or types of vesicles, and they confer specificity to vesicle trafficking by recruiting effector molecules that mediate vesicle movement, docking, and fusion. For example, Rab5 is well-known for its role in early endosome dynamics, facilitating the early stages of endocytosis and endosomal maturation. Rab7, on the other hand, is involved in the maturation of late endosomes and their fusion with lysosomes, crucial for the degradation of internalized material.
The diversity of the Rab family, with more than 60 members identified in human cells, allows for the fine-tuning of various trafficking pathways and ensures that cellular materials are delivered to the right place at the right time. This specificity and regulation are vital for maintaining cellular organization and function, particularly in cells with complex architecture such as neurons, where Rab proteins regulate synaptic vesicle trafficking essential for neurotransmitter release.
Rab proteins are also implicated in various diseases. Their dysfunction can disrupt normal vesicle trafficking, leading to diseases such as immune disorders, neurodegenerative diseases, and cancer. For instance, mutations in Rab7 have been linked to Charcot-Marie-Tooth type 2B disease, a peripheral neuropathy that affects the degradation and recycling of nerve cell components.
Figure 1 Rab proteins-mediated vesicular transport and signaling pathways. (Tzeng, 2016)
Representative Targets of Rab Proteins
RAB2
ATG5, or Autophagy-related 5, is a crucial protein involved in the autophagy pathway. The ATG5 protein is integral to the formation of the autophagosome, a key structure in autophagy, where it conjugates with ATG12 and associates with ATG16L1 to form the ATG12–ATG5-ATG16L1 complex. This complex is vital for the expansion of the autophagosome membrane. The activity of ATG5 is particularly important during cellular stress conditions, such as nutrient starvation, where it helps to ensure cellular survival by recycling intracellular components to generate new building blocks and energy. Moreover, ATG5 is involved in cellular processes that regulate immune responses, where it contributes to the elimination of intracellular pathogens and the presentation of antigens, playing a role in maintaining immune homeostasis. Dysregulation or defects in the autophagy process, involving ATG5, have been linked to various diseases, including neurodegenerative diseases, cancers, and infectious diseases. In neurodegeneration, impaired autophagy can lead to the accumulation of toxic protein aggregates, while in cancer, the role of autophagy is more complex, acting as a tumor suppressor in some contexts and promoting tumor survival in others. This dual role makes ATG5 a potential therapeutic target, with strategies aimed at modulating its activity to enhance or inhibit autophagy based on the specific disease context.
Recommended Mouse Anti-RAB2 mAb (CAT#: ZG-045R)
Figure 2 Mouse Anti-RAB2 Antibody (ZG-045R) in IF. Immunofluorescence analysis of HeLa cells using Rab 2A monoclonal antibody.
RAB5A
ATG7, or Autophagy-related 7, acts as an E1-like activating enzyme in the autophagy machinery, facilitating the conjugation of other ATG proteins necessary for autophagosome formation, specifically ATG8/LC3 to phosphatidylethanolamine and the ATG12-ATG5 conjugate formation, which are critical steps in the autophagic process. This protein is ubiquitously expressed and is essential not only for the routine turnover of cellular components but also for survival during nutrient deprivation by recycling intracellular resources. It plays a protective role in various stress conditions, including hypoxia, infection, and oxidative stress. The activity of ATG7 is crucial in processes beyond mere recycling; it's involved in immune responses through the regulation of inflammation and immunity mechanisms, and it also participates in the removal of invasive pathogens and the presentation of antigens. Dysfunction in ATG7 and the autophagy pathway is linked to numerous diseases, including neurodegenerative disorders like Parkinson’s and Alzheimer’s disease, where a buildup of protein aggregates can be detrimental. In cancer, similar to other autophagy-related genes, ATG7 can have dual roles: suppressing tumor initiation while potentially supporting tumor growth and resistance to therapy in established cancers. This complex role makes ATG7 a target of interest for therapeutic strategies aiming to manipulate autophagy for disease treatment.
Recommended Rabbit Anti-RAB5A mAb (CAT#: VS3-FY1232)
Figure 3 Recombinant Rabbit Anti-RAB5A Antibody (clone R01-6G5) in IHC-P. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Rab5 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Recommended Rabbit Anti-RAB5A mAb (CAT#: VS3-FY1233)
Figure 4 Recombinant Rabbit Anti-RAB5A Antibody (clone R06-4J3) in IHC-P. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Rab5 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
RAB10
BECN1, or Beclin 1, is a key regulator of autophagy, a critical cellular process for maintaining homeostasis through the degradation and recycling of cellular components. Beclin 1 is integral to the initiation phase of autophagy, primarily involved in the nucleation of autophagosomal membranes. It functions as part of the class III phosphatidylinositol 3-kinase (PI3K) complex, which is essential for the early steps of autophagosome formation. This protein is not only pivotal in autophagy but also plays significant roles in other important cellular processes, including apoptosis and cell proliferation. The activity of BECN1 is tightly regulated by interactions with various cofactors that either promote or inhibit its activity. For instance, its interaction with BCL-2, an anti-apoptotic protein, can inhibit autophagy by preventing the activation of the BECN1-dependent PI3K complex. Conversely, dissociation of BECN1 from BCL-2 is a critical step in the induction of autophagy, particularly under stress conditions such as nutrient deprivation or oxidative stress. BECN1 has been implicated in a range of diseases, including cancer, neurodegenerative diseases, and infections. In cancer, for example, reduced expression or mutations in the BECN1 gene can lead to decreased autophagic activity, promoting tumorigenesis and chemotherapy resistance. Conversely, in neurodegenerative diseases like Alzheimer's, enhanced activity of BECN1 may help in clearing abnormal protein aggregates, although excessive autophagy can also lead to cell death.
Recommended Mouse Anti-RAB10 mAb (CAT#: ZG-043R)
Figure 5 Mouse Anti-RAB10 Antibody (ZG-043R) in IF. Immunofluorescence analysis of LOVO cells using Rab 10 monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
Recommended Rabbit Anti-RAB10 mAb (CAT#: VS3-FY1231)
Figure 6 Recombinant Rabbit Anti-RAB10 Antibody (clone R06-2A3) in ICC. Immunocytochemical analysis of Rab10 (green) in A549 using Rab10 antibody and DAPI (blue).
Full List of Targets of Rab Proteins
| Biomarker | Alternative Names | Gene ID | UniProt ID | Roles |
| RAB10 | RAB10, Member RAS Oncogene Family; Ras-Related GTP-Binding Protein | 10890 | P61026 | RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009] |
| RAB11A | YL8 | 8766 | P62491 | The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. |
| RAB11B | RAB11B, Member RAS Oncogene Family; GTP-Binding Protein YPT3; RAB11B, Member Of RAS Oncogene Family; H-YPT3; YPT3 | 9230 | Q15907 | The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways. |
| RAB13 | GIG4 | 5872 | P51153 | This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. |
| RAB14 | FBP; RAB-14 | 51552 | P61106 | RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]). |
| RAB17 | RAB17; RAB17, member RAS oncogene family; ras-related protein Rab-17; FLJ12538; OTTHUMP00000164417; OTTHUMP00000202805; Rab 17; Rab17; RAB17 member RAS oncogene family; RAB17_HUMAN; Ras related protein Rab 17; Ras related protein Rab17; Ras-related protein Rab-17; OTTHUMP00000164417; OTTHUMP00000202805; | 64284 | Q9H0T7 | The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009] |
| RAB18 | RAB18; Member RAS Oncogene Family; Ras-Related Protein Rab-18; RAB18 Small GTPase; RAB18LI1; WARBM3 | 22931 | Q9NP72 | The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. |
| RAB19 | RAB19; RAB19, member RAS oncogene family; ras-related protein Rab-19; RAB19B; GTP-binding protein RAB19B; Ras-related protein Rab-19; OTTHUMP00000212106; OTTHUMP00000212107; GTP-binding protein RAB19B; | 401409 | A4D1S5 | |
| RAB1A | RAB1A; RAB1A, member RAS oncogene family; RAB1; ras-related protein Rab-1A | 403774 | Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene. RAB1A has been shown to interact with CHM, GOLGA5, CHML, RABAC1, MICAL1 and GOLGA2. | |
| RAB1B | RAB1B; Member RAS Oncogene Family | 81876 | Q9H0U4 | Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 ; Alvarez et al., 2003 ). |
| RAB2 | LHX; RAB2 | 5862 | P61019 | RAB2A belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| RAB20 | RAB20; Member RAS Oncogene Family | 55647 | Q9NX57 | RAB20 (RAB20, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB5C. |
| RAB21 | RAB21; Member RAS Oncogene Family; KIAA0118 | 23011 | Q9UL25 | This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. |
| RAB22A | RAB22A, Member RAS Oncogene Family; Rab-22; Ras-Related Protein Rab-22A; GTP-Binding Protein RAB22A; RAB22 | 57403 | Q9UL26 | The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. |
| RAB23 | RAB23; Member RAS Oncogene Family; RAB Family Small GTP Binding Protein RAB 23; Ras-Related Protein Rab-23; HSPC137 | 51715 | Q9ULC3 | This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. |
| Rab24 | RAB24, member RAS oncogene family | 53917 | Q969Q5 | RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking. |
| RAB25 | CATX-8; RAB11C | 57111 | P57735 | The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. |
| RAB26 | RAB26; RAB26, member RAS oncogene family; ras-related protein Rab-26; RAB26, member RAS oncogene family; Ras related oncogene protein; Ras related protein Rab 26; V46133; OTTHUMP00000159048; Ras-related oncogene protein; V46133; | 25837 | Q9ULW5 | Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010] |
| RAB27A | GS2; RAM; RAB27; HsT18676 | 5873 | P51159 | The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. |
| RAB27B | Ras-related protein Rab-27B; C25KG | 5874 | O00194 | Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. |
| RAB29 | RAB29, Member RAS Oncogene Family; RAB7, Member RAS Oncogene Family-Like 1; Ras-Related Protein Rab-29; Rab-7-Like Protein 1; RAB7L1; Ras-Related Protein Rab-7L1; RAB7L | 8934 | O14966 | RAB29 (RAB29, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB32. |
| RAB2A | LHX; RAB2 | 5862 | P61019 | The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| RAB2B | RAB2B; RAB2B, member RAS oncogene family; ras-related protein Rab-2B; FLJ14824; FLJ14824; GTP-binding protein RAB2B; RAB2B; RAB2B member RAS oncogene family; RAB2B_HUMAN; RAS family, member RAB2B; Ras-related protein Rab-2B; OTTHUMP00000195135; RAS family, member RAB2B; GTP-binding protein RAB2B; | 84932 | Q8WUD1 | Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006] |
| RAB30 | RAB30; RAB30, member RAS oncogene family; ras-related protein Rab-30; AI323892; OTTMUSP00000025678; Ras related protein Rab 30; Rsb30; 5033421K01Rik; OTTMUSP00000025677; RAB 30; RAB30, member RAS oncogene family; OTTHUMP00000234567; OTTHUMP00000234568; OTTHUMP00000234569; OTTHUMP00000234571; OTTHUMP00000234572; OTTHUMP00000234573; | 27314 | Q15771 | |
| RAB31 | RAB31; RAB31, member RAS oncogene family; ras-related protein Rab-31; Rab22B; Rab 22B; RAB 31; Rab22B; RAB31 member RAS oncogene family; Ras related protein Rab 31; Ras related protein Rab31; ras-related protein Rab-22B; | 11031 | Q13636 | Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009] |
| RAB33A | RAB33A; RAB33A, member RAS oncogene family; ras-related protein Rab-33A; RabS10; MGC1488; RAB 33A; Rab33a; RAB33A member RAS oncogene family; RabS 10; RabS10; Ras related protein Rab 33A; Ras related protein Rab33A; Ras-related protein Rab-33A; RB33A_HUMAN; Small GTP binding protein S10; Small GTP-binding protein S10; OTTHUMP00000024006; Small GTP-binding protein S10; | 9363 | Q14088 | The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008] |
| RAB33B | RAB33B; RAB33B, member RAS oncogene family; ras-related protein Rab-33B; DKFZP434G099; DKFZP434G099; MGC138182; RAB 33B; RAB33B member RAS oncogene family; Ras related protein Rab 33B; Ras related protein Rab33B; OTTHUMP00000164542; | 83452 | Q9H082 | Small GTP-binding proteins of the RAB family, such as RAB33B, play important roles at defined steps of vesicular transport in protein secretion and the endocytosis pathway (Zheng et al., 1998 [PubMed 9512502]).[supplied by OMIM, Feb 2010] |
| RAB38 | rrGTPbp; NY-MEL-1 | 23682 | P57729 | |
| RAB39B | WSMN; MRX72 | 116442 | Q96DA2 | This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked mental retardation. |
| RAB3A | RAB3A, member RAS oncogene family | 5864 | P20336 | Enables GTPase activity and myosin V binding activity. Involved in several processes, including acrosomal vesicle exocytosis; lysosome localization; and plasma membrane repair. Located in perinuclear region of cytoplasm. |
| RAB3B | RAB3B, member RAS oncogene family | 5865 | P20337 | Enables GDP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic vesicle cycle; and regulation of vesicle size. Located in perinuclear region of cytoplasm and vesicle. Is active in dopaminergic synapse. Is anchored component of synaptic vesicle membrane. |
| RAB3D | GOV; D2-2; RAB16; RAD3D | 9545 | O95716 | |
| RAB4 | HRES-1; HRES-1/RAB4; HRES1; RAB4 | 5867 | P20338 | RAB4A is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. |
| RAB42 | RAB42; RAB42, member RAS oncogene family; RAB42, member RAS homolog family; putative Ras-related protein Rab-42; MGC45806; Putative Ras-related protein Rab-42; OTTHUMP00000003787; RP4-669K10.6; | 115273 | Q8N4Z0 | |
| RAB43 | RAB43; RAB43, member RAS oncogene family; ras-related protein Rab-43; ISY1; RAB11B; RAB41; RAB41; Ras related protein Rab 41; Ras related protein Rab 43; OTTHUMP00000174305; OTTHUMP00000174306; OTTHUMP00000174307; OTTHUMP00000174308; OTTHUMP00000174309; OTTHUMP00000217104; ras-related protein Rab-41; | 339122 | Q86YS6 | |
| RAB4A | RAB4A, Member RAS Oncogene Family; RAB4; HTLV-1 Related Endogenous Sequence; Ras-Related Protein Rab-4A; HRES-1/RAB4; HRES-1; HRES1 | 5867 | P20338 | This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. |
| RAB5A | RAB5A, Member RAS Oncogene Family; RAS-Associated Protein RAB5A; RAB5; Ras-Related Protein Rab-5A | 5868 | P20339 | RAB5A (RAB5A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5A include Motor Neuron Disease and Tuberous Sclerosis 2. Among its related pathways are Delta508-CFTR traffic / Sorting endosome formation in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C. |
| RAB5C | RAB5C, Member RAS Oncogene Family; RAB5C, Member Of RAS Oncogene Family; L1880; RAB5L; RABL; RAB, Member Of RAS Oncogene Family-Like; Ras-Related Protein Rab-5C; RAB5CL | 5878 | P51148 | Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010] |
| Rab6 | Rab6 | Recombinant antibodies specific to the guanosine triphosphate (GTP)-bound conformation of the small guanosine triphosphatase (GTPase) Rab6, a regulator of membrane traffic, were generated and used to locate Rab6.GTP in fixed cells, and, after green fluorescent protein (GFP) tagging and intracellular expression, to follow Rab6.GTP in vivo. Rab6 was in its GTP-bound conformation on the Golgi apparatus and transport intermediates, and the geometry of transport intermediates was modulated by Rab6 activity. More generally, the same approach could be applied to other molecules that can be locked in a particular conformation in vitro. | ||
| RAB6A | RAB6A; RAB6A, member RAS oncogene family; RAB6; ras-related protein Rab-6A; GTP binding protein RAB6B; Oncogene RAB6; Rab GTPase; Rab6A variant 3; GTP binding protein RAB6A; Rab 6; RAB6; RAB6 member RAS oncogene family; RAB6A member RAS oncogene family; RAB6A; RAB6B; Ras related protein Rab 6A; RCO4 3; Rab GTPase; OTTHUMP00000165966; OTTHUMP00000165967; OTTHUMP00000237641; OTTHUMP00000237642; OTTHUMP00000237643; OTTHUMP00000237666; RAB6, member RAS oncogene family; | 5870 | P20340 | This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| RAB6B | RAB6B; Member RAS Oncogene Family | 51560 | Q9NRW1 | RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB6A. |
| RAB7A | RAB7A, Member RAS Oncogene Family; RAB7, Member RAS Oncogene Family; RAB7; Ras-Associated Protein RAB7; Ras-Related Protein Rab-7a; PRO2706 | 416016 | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] | |
| RAB7B | RAB7B, Member RAS Oncogene Family; Ras-Related Protein Rab-7b; Ras-Related Protein Rab-7; RAB7 | 338382 | Q96AH8 | RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB7A. |
| RAB8A | RAB8A, Member RAS Oncogene Family; Mel Transforming Oncogene (Derived From Cell Line NK14); Oncogene C-Mel; RAB8; MEL; Mel Transforming Oncogene (Derived From Cell Line NK14)- RAB8 Homolog; Mel Transforming Oncogene (RAB8 Homolog); Ras-Associated Protein RAB8; Ras-Related Protein Rab-8A | 4218 | P61006 | The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. |
| RAB8B | RAB8B; RAB8B, member RAS oncogene family; ras-related protein Rab-8B; D330025I23Rik; GTPase Rab8b; 5930437D16; FLJ38125; RAB 8b protein; RAB44; Rab8b; RAB8B, member RAS oncogene family; RAB8B_HUMAN; Ras-related protein Rab-8B; RAB-8b protein; OTTHUMP00000163760; | 51762 | Q92930 | RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010] |
| RAB9A | RAB9 | 9367 | P51151 | Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. |
Tested Data-Supported Products for Targeting Rab Proteins
| CAT | Product Name | Biomarker | Assay | Image |
| ZG-043R | Mouse Anti-RAB10 Recombinant Antibody (ZG-043R) | RAB10 | WB |  |
| ZG-044R | Mouse Anti-RAB25 Recombinant Antibody (ZG-044R) | RAB25 | WB |  |
| ZG-045R | Mouse Anti-RAB2 Recombinant Antibody (ZG-045R) | RAB2 | WB |  |
| ZG-046R | Mouse Anti-RAB2 Recombinant Antibody (ZG-046R) | RAB2 | WB |  |
| ZG-047R | Mouse Anti-RAB4 Recombinant Antibody (ZG-047R) | RAB4 | WB |  |
| VS3-FY1231 | Recombinant Rabbit Anti-RAB10 Antibody (clone R06-2A3) | RAB10 | WB |  |
| VS3-FY1232 | Recombinant Rabbit Anti-RAB5A Antibody (clone R01-6G5) | RAB5A | WB |  |
| VS3-FY1233 | Recombinant Rabbit Anti-RAB5A Antibody (clone R06-4J3) | RAB5A | WB |  |
| VS3-FY1234 | Recombinant Rabbit Anti-RAB5C Antibody (clone R04-3B7) | RAB5C | WB |  |
| VS3-FY1235 | Recombinant Rabbit Anti-RAB7A Antibody (clone R01-3K3) | RAB7A | WB |  |
| VS3-FY1236 | Recombinant Rabbit Anti-RAB7A Antibody (clone R07-8G1) | RAB7A | IHC-P |  |
| VS3-FY1237 | Recombinant Rabbit Anti-RAB7B Antibody (clone R08-2C5) | RAB7B | WB |  |
Reference
- Herzig, Sébastien, and Reuben J. Shaw. "AMPK: guardian of metabolism and mitochondrial homeostasis." Nature reviews Molecular cell biology 19.2 (2018): 121-135.
For research use only. Not intended for any clinical use.
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