Anti-ABCG1 Products

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For Research Use Only. Not For Clinical Use.

Explore cardiovascular and metabolic disease research with the help of Creative Biolabs' anti-ABCG1 recombinant antibodies. ABCG1 is an important transporter responsible for mediating cholesterol efflux to HDL, thus playing a key role in the reverse cholesterol transport pathway and anti-atherogenic processes. The high-quality rAbs offered by Creative Biolabs are specially designed to help you study lipid metabolism, macrophage biology, and mechanisms to facilitate cholesterol removal, among other aspects.

ABCG1: A Key Transporter in Reverse Cholesterol Transport

ATP-binding cassette subfamily G member 1 (ABCG1) is a cholesterol transporter involved in maintaining cellular lipid homeostasis. The transporter is widely expressed in macrophages, endothelial cells, and various tissues. ABCG1's main function is to facilitate the efflux of excess cellular cholesterol, particularly to mature forms of high-density lipoprotein (HDL) particles. The transporter is thus a major player in reverse cholesterol transport, an important anti-atherogenic pathway where cholesterol is removed from the atherosclerotic plaques in artery walls by being delivered from foam cells to HDL particles. For this reason, normal ABCG1 function is essential for preventing cholesterol accumulation in the artery wall.

Alternative Names

ABCG1; ATP-Binding Cassette, Sub-Family G (WHITE), Member 1; Homolog Of Drosophila White; ATP-Binding Cassette Transporter 8; WHT1; WHITE1; White Protein Homolog (ATP-Binding Cassette Transporter 8); White Protein Homolog; ABC8

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Anti-ABCG1 rAb Products

Creative Biolabs' anti-ABCG1 recombinant antibodies are designed for high specificity and robust performance. The rAbs are carefully validated to specifically detect the ABCG1 transporter in cells, including macrophages. Optimized for various applications such as Western Blot and immunofluorescence to study subcellular localization, these rAbs are engineered for the reliability and clarity you need to study this important metabolic pathway.

Table 1. Featured anti-ABCG1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has developed robust production platforms to ensure the quality of your scientific tools. We express our anti-ABCG1 recombinant antibodies in an optimized system so you can be sure they will accurately detect the native transporter. The rAbs produced by our team are specialized for high specificity and activity, giving you the ideal antibody for your experiments.

Featured Anti-ABCG1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ABCG1 recombinant antibody production.

Fig.2 Gram-scale anti-ABCG1 recombinant antibody production.

rAb Modalities

Creative Biolabs is on a mission to support and empower scientific discovery with its highly customizable antibody modalities. We make it simple for you to access our anti-ABCG1 recombinant antibodies in a variety of formats, allowing researchers around the world to study this important transporter in the context of cardiovascular health.

Fig.3 Full-length anti-ABCG1 recombinant antibody production and modalities.

Study the important role of ABCG1 in cellular cholesterol homeostasis with the high-quality recombinant antibodies from Creative Biolabs. Our portfolio is known for its high specificity and extensive validation, making it the perfect set of tools for your research in atherosclerosis and metabolic disease. Choose Creative Biolabs for quality that will help you discover faster. Get in touch with one of our experts today.