Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Intracellular, Secreted (different isoforms)
Cell type enhanced (Peritubular cells, Fibroblasts, Smooth muscle cells, Leydig cells, Endometrial stromal cells)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (ASC diff, BJ, BJ hTERT+, fHDF/TERT166, JURKAT, WM-115)
Isoform 1: Interacts with different types of collagen, including collagens I, III, and V (PubMed:29606302). Isoform 2: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro.
Calmodulin-binding, DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.