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AIM2
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- PE-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC191)
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- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: PE
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- APC-A*01:01/Human AIM2 (RSDSGQQARY) MHC Tetramer (MHC-LC192)
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- Class: Class I
- Antigen: Antigen isolated from immunoselected melanoma-2 (AIM2)
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: APC
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- A*01:01/Human AIM-2 (RSDSGQQARY) MHC Pentamer (MHC-YF316)
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- Class: Class I
- Antigen: AIM-2
- Antigen Species: Human
- Peptide: RSDSGQQARY
- Conjugate: Unlabeled, Biotin, R-PE, APC
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For Research Use Only. Not For Clinical Use.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Predicted location
Intracellular
Single cell type specificity
Group enriched (B-cells, Plasma cells, Late spermatids, Early spermatids)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70, U-266/84, U-87 MG)
Interaction
Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform (PubMed:15582594, PubMed:19158676). Component of the AIM2 inflammasome (PubMed:22869553, PubMed:22483801). Interacts with PYCARD, IFI16, EIF2AK2/PKR and MAPRE1 (PubMed:19158676, PubMed:19158675, PubMed:19158679, PubMed:22046441, PubMed:22801494, PubMed:22869553). Interacts with PYDC5; disrupts assembly of the ALR inflammasome complex (PubMed:24531343). Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis) (By similarity).
Molecular function
DNA-binding
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