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This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer.
Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SH-SY5Y)

Interaction

Homodimer; homodimerizes following heparin- and ligand-binding (PubMed:16317043, PubMed:25605972, PubMed:34646012, PubMed:34819673). Interacts with CBL, IRS1, PIK3R1 and PLCG1 (PubMed:15226403). Interacts with FRS2 and SHC1 (PubMed:15226403, PubMed:16878150, PubMed:17274988). Interacts with PTN and MDK (PubMed:11278720, PubMed:12122009).

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
More Infomation

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