Anti-AQP1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is paving the way in oncology and renal physiology research with superior anti-Aquaporin 1 (AQP1) recombinant antibodies. AQP1 is a critical water channel involved in both fluid homeostasis and tumor angiogenesis/metastasis. Our recombinant antibodies are a key resource for studying AQP1 expression and function in normal physiology and disease.

AQP1: A Water Channel Fueling Angiogenesis and Cell Migration

Aquaporin 1 (AQP1) is a transmembrane protein that forms channels for rapid water transport across the cell membrane. AQP1 has a critical function in urine concentration in the kidney and regulation of tissue fluid balance in organs such as lung and brain. In cancer, AQP1 is upregulated in the microvasculature of many aggressive tumors. AQP1 has been shown to promote endothelial cell migration and angiogenesis by allowing rapid changes in cell shape and volume. AQP1 is a potential target for anti-angiogenic cancer therapy.

Alternative Names

AQP1; Channel-Like Integral Membrane Protein, 28-KDa; Aquaporin-1; Aquaporin 1 (Channel-Forming Integral Protein, 28kDa); CO; AQP-1; Urine Water Channel; Colton Blood Group; Water Channel Protein For Red Blood Cells And Kidney Proximal Tubule; Aquaporin 1

Background

This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement.

Anti-AQP1 rAb Products

Creative Biolabs' anti-AQP1 recombinant antibodies have been developed for optimal specificity and high affinity. This is critical for reliable detection of this important membrane protein. We validate our anti-AQP1 rAbs in demanding applications such as flow cytometry and immunohistochemistry (IHC) on tumor sections. The antibodies have the precision and accuracy you need to study the expression and function of AQP1 without cross-reactivity to other AQP family members.

Table 1. Featured anti-AQP1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Our customers can trust Creative Biolabs for quality and consistency. Production of our recombinant antibodies uses a rigorous quality assurance system. The antibodies are tested thoroughly before each shipment to confirm that the batch meets the highest standards of purity, binding kinetics and consistent performance in expected applications. With Creative Biolabs, you can be confident that you will receive a reagent of the highest quality for your work on this critical target.

Customer Reviews

rAb Production

Creative Biolabs has developed advanced antibody production platforms to make our elite recombinant antibodies. We leverage optimized mammalian expression systems to ensure that the proper tetrameric assembly and membrane insertion of AQP1 are maintained for recognition by our antibodies. This means a final product with superior biological relevance and activity to meet your research needs.

Featured Anti-AQP1 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-AQP1 recombinant antibody production.

Fig.4 Gram-scale anti-AQP1 recombinant antibody production.

rAb Modalities

Creative Biolabs provides a full portfolio of anti-AQP1 antibody formats to support the discovery needs of researchers around the world. We offer a range of customizable options from full-length IgGs for in vivo studies of anti-angiogenic effects to Fab fragments for structural studies. You can count on Creative Biolabs to help you pursue the most relevant format for your investigations of this transmembrane channel.

Fig.5 Full-length anti-AQP1 recombinant antibody production and modalities.

Take your research on AQP1-mediated angiogenesis and fluid transport to the next level with Creative Biolabs' recombinant antibodies. With a focus on stringent validation and unmatched consistency, our portfolio offers the ideal tool for your most challenging projects. Let us partner with you for quality that powers discovery. Contact our experts today.