Anti-ASNS Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in cancer metabolism research, providing elite anti-Asparagine Synthetase (ASNS) recombinant antibodies. ASNS, the only enzyme responsible for the endogenous production of asparagine, plays a crucial role in cancer cell survival and is a key determinant of resistance to asparaginase therapy. Our high-quality recombinant antibodies are essential tools for exploring metabolic vulnerabilities in cancer and developing strategies to overcome drug resistance.

ASNS: A Key Survival Enzyme in Cancer and a Marker of Asparaginase Resistance

Asparagine Synthetase (ASNS) is a cytosolic enzyme that catalyzes the ATP-dependent conversion of aspartate and glutamine to asparagine. This is the only pathway by which human cells can produce their own asparagine. Although most normal cells can produce asparagine at levels that exceed their requirements, certain cancers, such as acute lymphoblastic leukemia (ALL), have low ASNS expression and are unable to synthesize sufficient asparagine to support cell growth. This "ASNS dependency" is the therapeutic basis for L-asparaginase therapy, which depletes serum asparagine and preferentially starves the cancer cells of this essential amino acid. However, one of the major mechanisms by which cancer cells become resistant to L-asparaginase treatment is through ASNS upregulation. ASNS is therefore an attractive biomarker of asparaginase resistance, and a target for combinatorial approaches to sensitize tumors to asparagine depletion.

Alternative Names

ASNS; TS11 Cell Cycle Control Protein; EC 6.3.5.4; Glutamine-Dependent Asparagine Synthetase; ASNSD; Asparagine Synthetase (Glutamine-Hydrolyzing); TS11; Asparagine Synthetase; Asparagine Synthetase [Glutamine-Hydrolyzing]

Background

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene.

Anti-ASNS rAb Products

Our anti-ASNS recombinant antibodies are designed and validated to the highest specificity and sensitivity so you can confidently detect the ASNS enzyme in cancer cell lines and tumor tissues. They are extensively validated for the most demanding applications such as Western Blot for analysis of expression levels, or IHC to study its distribution in the tumor microenvironment, and will provide clear and actionable data for your oncology research.

Table 1. Featured anti-ASNS recombinant antibody products at Creative Biolabs.

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rAb Production

Creative Biolabs is focused on enabling the next breakthrough in oncology by taking advantage of advanced antibody production platforms. Our anti-ASNS recombinant antibodies are expressed in highly optimized systems to ensure accurate recognition of the native enzyme, resulting in a product with high biological activity that is relevant for your cancer metabolism research.

Featured Anti-ASNS Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ASNS recombinant antibody production.

Fig.2 Gram-scale anti-ASNS recombinant antibody production.

rAb Modalities

Creative Biolabs is your partner in building better tools for cancer research. Our anti-ASNS recombinant antibodies are available in a variety of customizable formats to meet the unique needs of your experiments, giving researchers around the world the tools they need to understand this important resistance mechanism and develop more effective therapies for cancer.

Fig.3 Full-length anti-ASNS recombinant antibody production and modalities.

Explore the mechanisms of asparaginase resistance with precision using Creative Biolabs' anti-ASNS recombinant antibodies. From rigorous validation to exceptional lot-to-lot consistency, our portfolio is designed to provide you with the tools to study this key metabolic vulnerability in cancer. Partner with us for quality you can rely on. Contact our experts today.