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ATF3
Loading...Anti-ATF3 Products
- Mouse Anti-ATF3 Recombinant Antibody (clone 7G10) (MOB-0678MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- Anti-ATF3 Immunohistochemistry Kit (VS-0525-XY576)
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- Species Reactivity: Human
- Target: ATF3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal squamous epithelial cells, Glandular and luminal cells, Endometrial ciliated cells)
Immune cell specificity
Group enriched (basophil, non-classical monocyte, intermediate monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (BEWO, HDLM-2, SuSa)
Interaction
Binds DNA as a homodimer or a heterodimer. Interacts with KAT5; promoting KAT5 autoacetylation and KAT5 deubiquitination by USP7 (PubMed:25865756).
Molecular function
DNA-binding, Repressor
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