Anti-BIRC7 Products

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For Research Use Only. Not For Clinical Use.

Enhance your oncology research with high-quality and highly specific anti-BIRC7 (ML-IAP) recombinant antibodies from Creative Biolabs. BIRC7, a member of the inhibitor of apoptosis protein family with restricted expression and a metastasis-promoting function, is gaining attention as a potential therapeutic target in melanoma and other cancers. We have a portfolio of premium antibodies to support your studies on its role in cell survival, invasion, and other biological processes.

BIRC7: An IAP Promoting Melanoma Survival and Metastasis

The Baculoviral IAP Repeat Containing 7 (BIRC7) gene also known as Melanoma Inhibitor of Apoptosis Protein (ML-IAP) or Livin, is a member of the IAP family of proteins. It features a single BIR domain with the ability to bind and inhibit caspases, and a RING domain that confers E3 ubiquitin ligase activity. It is expressed at low levels in most normal tissues, but is often highly upregulated in melanoma and is a key driver of tumor cell survival and resistance to apoptosis. It has also been linked to promoting metastatic potential in cancer cells. Its restricted expression and pro-tumorigenic roles make it a promising target for cancer therapy.

Alternative Names

BIRC7; Melanoma Inhibitor Of Apoptosis Protein; RNF50; Livin Inhibitor Of Apoptosis; EC 6.3.2.-; Livin Inhibitor-Of-Apoptosis; Baculoviral IAP Repeat-Containing 7; Baculoviral IAP Repeat-Containing Protein 7; RING Finger Protein 50; Baculoviral IAP Repeat

Background

The gene product belongs to the inhibitor of apoptosis protein (IAP) family. It contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The encoded protein is highly expressed and may have a role in cancer progression. It is also involved in the sensitivity to chemotherapy. Alternative splicing generates multiple transcript variants.

Anti-BIRC7 rAb Products

Our anti-BIRC7 recombinant antibodies are designed with high specificity and strong performance in mind. They are carefully validated to ensure accurate detection of the BIRC7 protein and its splice variants. Optimized for applications like Western Blot to measure expression in tumor cell lines and IHC to study its localization, these rAbs are built to deliver the consistency and reliability you need for your cutting-edge oncology research.

Table 1. Featured anti-BIRC7 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to supporting the specialized needs of cancer research with our leading-edge antibody production platforms. Our anti-BIRC7 recombinant antibodies are expressed in an optimized system that ensures the antibody accurately recognizes the native protein, delivering a highly specific and active antibody for your experiments.

Featured Anti-BIRC7 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-BIRC7 recombinant antibody production.

Fig.2 Gram-scale anti-BIRC7 recombinant antibody production.

rAb Modalities

Creative Biolabs empowers scientific discoveries with a flexible portfolio of antibody solutions. Our anti-BIRC7 recombinant antibodies are available in a range of customizable modalities to meet your unique experimental requirements, giving researchers around the world the tools to study this important oncogenic protein.

Fig.3 Full-length anti-BIRC7 recombinant antibody production and modalities.

Discover the important functions of BIRC7 in melanoma and other cancers with Creative Biolabs' recombinant antibodies. Our products are characterized by their high specificity and extensive validation, making them the ideal research tools for your studies. Choose Creative Biolabs for quality that powers discovery. Contact our experts today.