Anti-CAMK4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted provider of immunology and neuroscience reagents, and we are offering you our anti-CAMK4 recombinant antibodies. CAMK4 is a critical nuclear kinase that transduces calcium signals into changes in gene expression, and thereby regulates immune cell function and neuronal development. Our high quality antibodies are the tool you need to study its role in autoimmunity, inflammation and learning.

CAMK4: A Nuclear Decoder of Calcium Signals

Calcium/Calmodulin-Dependent Protein Kinase IV (CAMK4) is a serine/threonine kinase whose predominant localization is the nucleus. It is activated by the upstream kinase CaMKK in response to sustained calcium signaling. Once active, CAMK4's primary role is to phosphorylate a wide array of transcription factors, most prominently CREB (cAMP-response element-binding protein). This phosphorylation is a crucial step in activity-dependent gene expression in both the immune system (e.g., during T-cell differentiation) and the nervous system (e.g., during long-term memory formation). Dysregulation, particularly over-activity, of CAMK4 is linked to autoimmune conditions such as lupus.

Alternative Names

caMK; CaMKIV; CaMK IV; CaMK-GR

Background

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and CAMK4, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene.

Anti-CAMK4 rAb Products

Our anti-CAMK4 recombinant antibodies are engineered for superior specificity and performance. They are stringently validated to recognize and detect the CAMK4 protein in nuclear extracts. Optimized for applications such as Western Blot to monitor expression levels and Chromatin Immunoprecipitation (ChIP) to study its recruitment to gene promoters, our rAbs offer the quality and consistency you need for your molecular biology research.

Table 1. Featured anti-CAMK4 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs does not compromise on scientific rigor. The production of our anti-CAMK4 recombinant antibodies is underpinned by a robust quality control framework. We thoroughly test each lot for purity, specificity (against other CaMK family members), and performance across validated applications. You can count on us to deliver a reagent of the highest quality.

Fig.1 WB analysis of anti-CAMK4 antibody (Cat# ZG-0257F, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is equipped with cutting edge antibody production platforms, enabling us to support your specialized needs in immunology. Our anti-CAMK4 recombinant antibodies are expressed in systems that have been optimized to ensure that they accurately recognize the native nuclear kinase, so that you get a highly specific and active tool for your experiments.

Featured Anti-CAMK4 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CAMK4 recombinant antibody production.

Fig.3 Gram-scale anti-CAMK4 recombinant antibody production.

rAb Modalities

At Creative Biolabs, we are committed to advancing science by providing you with flexible solutions. We understand that researchers need access to a wide range of modalities and we are here to enable you to get the tools you need. Our anti-CAMK4 recombinant antibodies are available in a range of customizable formats, to meet your diverse experimental needs, and empower researchers all over the world to study this crucial transcriptional regulator.

Fig.4 Full-length anti-CAMK4 recombinant antibody production and modalities.

Decipher the secrets of calcium-dependent gene expression with Creative Biolabs' anti-CAMK4 recombinant antibodies. With our rigorous validation and commitment to consistency, you can confidently investigate this key therapeutic target in autoimmunity. Place your trust in our expertise and provide your research with a strong foundation. Reach out to our scientific team today.