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    CCR2

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    For Research Use Only. Not For Clinical Use.


    Background

    CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Cd3zeta Deficiency. Among its related pathways are Cytokine Signaling in Immune system and Defensins. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.
    CCR2
    Protein class

    CD markers, G-protein coupled receptors, Human disease related genes

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Kupffer cells, dendritic cells, monocytes, Plasma cells, Macrophages)

    Immune cell specificity

    Immune cell enhanced (basophil)

    Cell line specificity

    Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)

    Interaction

    Interacts with ARRB1 (PubMed:9501202). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (PubMed:15995708, 25283965). (Microbial infection) Binds to HIV-1 Tat.

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

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