CD19
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Species Reactivity: Human
Type: Mouse IgG1
Application: IHC
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG1
Application: WB, FC, ICC, IF, FuncS
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Derivation: Phage display library screening
Species Reactivity: Human
Type: Rabbit IgG
Application: IHC-P
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Species Reactivity: Mouse
Type: Rat IgG2a
Application: Depletion, Block, FC
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Species Reactivity: Human, Chimpanzee
Type: Mouse IgG1, κ
Application: FC, CyTOF, IHC, Block
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Species Reactivity: Human
Type: Mouse IgG1
Application: Neut, FC, IHC, IHC-Fr, IP
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Species Reactivity: Human
Type: Chicken antibody
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scFv
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1, κ
Application: Cyt, FuncS, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human, Cynomolgus monkey
Type: Human IgG1
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human, Cynomolgus monkey
Type: Humanized IgG
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human, Cynomolgus monkey
Type: Humanized IgG
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1, κ
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1, κ
Application: ELISA, FC
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Derivation: Humanized
Species Reactivity: Human
Type: IgG1, κ
Application: ELISA, IHC, FC, IP, IF, FuncS
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Host Species: Human
Specificity: Human
Type: Humanized antibody
Glycosylation site: Asn297 in Fc region
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Host Species: Human
Specificity: Human
Type: Humanized antibody
Glycosylation site: Asn297 in Fc region
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Host Species: Mouse
Specificity: Human
Type: Mouse antibody
Glycosylation site: Fc region
Glycoform (ratio): G2-NANA
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Host Species: Human
Specificity: Human
Type: Chimeric antibody (mouse/human)
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): GN-GN-M-(M-GN)2
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Host Species: Human
Specificity: Human
Type: Chimeric antibody (mouse/human)
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): GN-GN-M-(M-GN)2
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Type: Fully human antibody
Application: Depletion
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Type: Fully human antibody
Application: Depletion
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Derivation: Humanized
Type: Humanized antibody
Application: Depletion, ELISA
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Application: FC, Inhib, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC, Apop, ADCC, FuncS
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Derivation: Chimeric (mouse/human)
Type: Chimeric antibody (mouse/human)
Application: FuncS
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Chimeric (mouse/human) Fab
Application: FuncS
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Chimeric (mouse/human) Fab
Application: Depletion, FuncS
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: Depletion, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: Depletion, FuncS
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Type: Fully human antibody
Application: Depletion
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Type: Fully human antibody
Application: Depletion
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Derivation: Humanized
Type: Humanized antibody
Application: Depletion, ELISA
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Application: FC, Inhib, ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC, Apop, ADCC, FuncS
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Derivation: Chimeric (mouse/human)
Type: Chimeric antibody (mouse/human)
Application: FuncS
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Mouse scFv
Application: FuncS
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Mouse scFv
Application: Depletion, FuncS
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scFv
Application: Depletion, FuncS
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Species Reactivity: Human
Type: Mouse scFv
Application: Depletion, FuncS
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Type: Fully human antibody
Application: Depletion
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Type: Fully human antibody
Application: Depletion
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Derivation: Humanized
Type: Humanized antibody
Application: Depletion, ELISA
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Application: FC, Inhib, ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC, Apop, ADCC, FuncS
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Derivation: Chimeric (mouse/human)
Type: Chimeric antibody (mouse/human)
Application: ADCC, FuncS
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Chimeric (mouse/human) IgG
Application: FuncS
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Chimeric (mouse/human) IgG1
Application: Cyt, FC, FuncS, Inhib
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1
Application: Depletion, FuncS
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Species Reactivity: Human
Type: Mouse IgG2a, κ
Application: Depletion, FuncS
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Target: CD19
Linker: mc-vc (maleimidocaproyl-valine-alanine)
Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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Target: CD19
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD19
Linker: mc (maleimidocaproyl)
Drug: MMAF (monomethyl auristatin F)
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Target: CD19
Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug: MMAE (monomethyl auristatin E)
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Target: CD19
Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Target: CD19
Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Target: CD19
Linker: VC (valine-citrulline)
Drug: duocarmycin
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Target: CD19
Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Target: CD19
Linker: mc (maleimidocaproyl)
Drug: MMAF (monomethyl auristatin F)
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Target: CD19
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD19
Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Target: CD19
Linker: Mc (maleimidocaproyl)
Drug: MMAE (Monomethyl auristatin E)
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Target: CD19
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD19
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD19
Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug: MMAE (Monomethyl auristatin E)
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Derivation: Human
Species Reactivity: Human
Type: ADCC enhanced antibody
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Derivation: Human
Species Reactivity: Human
Type: Antibody
Application: FC, ADCC, FuncS
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1, κ
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Derivation: Humanized
Species Reactivity: Human
Type: IgG1 - kappa
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG1, κ
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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