CD33
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Class: Class I
Antigen: CD33
Antigen Species: Human
Peptide: AIISGDSPV
Conjugate: APC
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Class: Class I
Antigen: CD33 A65Y
Antigen Species: Human
Peptide: YIISGDSPV
Conjugate: PE
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG1, κ
Application: ELISA, FC, IF, IHC, IP, FuncS
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Llama VHH
Application: WB, IP, ChiP, Neut, ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC, FuncS
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Host Species: Human
Specificity: Human
Type: Humanized antibody
Glycosylation site: Asn73 in FR of VH
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Type: Human antibody
Application: FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Cynomolgus monkey
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Cynomolgus monkey
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, FC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Type: Human antibody
Application: FC
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Type: Human antibody
Application: FC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, Cyt
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: IgG
Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, IF, RIA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, Cyt
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Target: CD33
Linker: VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug: MMAE (Monomethyl auristatin E)
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, IF, RIA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, IF, RIA
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Target: CD33
Linker: mc-VC (maleimidocaproyl-valine-citrulline)
Drug: pyrrolobenzodiazepine (PBD) dimers
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Target: CD33
Linker: mc-vc (maleimidocaproyl-valine-alanine)
Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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Target: CD33
Linker: SPDB
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Target: CD33
Linker: acetyl butyrate linker
Drug: calicheamicin
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Target: CD33
Linker: hydrazone
Drug: Calicheamicin
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Target: CD33
Linker: mc-VC (maleimidocaproyl-valine-alanine)
Drug: pyrrolobenzodiazepine (PBD) dimers
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Target: CD33
Linker: DOTA-SH
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Target: CD33
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD33
Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Target: CD33
Linker: DOTA-NCS
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Target: CD33
Linker: Mc (maleimidocaproyl)
Drug: MMAF (Monomethyl auristatin F)
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Target: CD33
Linker: DOTA-G3FC
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Target: CD33
Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
Drug: Calicheamicin
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Target: CD33
Linker: AcBut
Drug: Calicheamicin
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Target: CD33
Drug: calicheamicin
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: Humanized (from mouse) IgG4, κ
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: IgG1 - kappa
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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For Research Use Only. Not For Clinical Use.