CD8 & IL2
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12.
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- Targets: CD8 & IL2
- Type: CrossMab
- Application: FuncS, Promising therapeutic agent
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- Species Reactivity: Human
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
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- Species Reactivity: Mouse
- Type: Mouse scFv
- Application: WB, ELISA, FuncS
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- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: WB, ELISA, FuncS
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- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: ELISA, FC, FuncS
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- Species Reactivity: Mouse
- Type: Mouse scFv
- Application: Neut
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- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: Neut
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- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: FC, FuncS, IHC, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, IHC, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: IHC, Neut
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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- Species Reactivity: Human, Non-Human Primate
- Type: Rat IgG2a
- Application: Neut
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, Neut, FuncS
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- Derivation: Rat
- Species Reactivity: Mouse
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, Neut, FuncS
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- Derivation: Rat
- Species Reactivity: Mouse
- Type: IgG
- Application: WB, ELISA, FuncS
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- Derivation: Rat
- Species Reactivity: Mouse
- Type: scFv
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, Neut, FuncS
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- Species Reactivity: Mouse
- Type: Rat IgG2a, κ
- Application: WB, Neut, ELISA
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: ELISA, IP, Neut
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: IP, IHC-Fr, Neut, FC
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Block, ELISA, WB
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Human IgG1, λ
- Application: Inhib, ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, Neut, IHC, IHC-Fr
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: CyTOF, ICC, ICFC, Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IP, IF, ELISA
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: WB, IP, IF, ELISA
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG4, κ
- Application: WB, IP, IF, ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a, κ
- Application: DB, IHC, Neut
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, Block
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: FC, IHC, IP, Neut
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: ELISA, Neut, ICFC, IP, IHC
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: ELISA, Neut
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- Species Reactivity: Mouse
- Type: Rat IgG1
- Application: ELISA, Neut
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- Species Reactivity: Macaca nemestrina, Human
- Type: Human IgG1
- Application: Immunotoxin, IP, FC, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: FuncS, Neut
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, ELISA, FC, IHC
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human, Monkey
- Type: Human IgG
- Application: ELISA
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- Species Reactivity: Human, Rabbit
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human, Rabbit
- Type: Human scFv
- Application: ELISA, FC
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- Species Reactivity: Human, Rabbit
- Type: Human IgG
- Application: ELISA, FC
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- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FuncS
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- Species Reactivity: Mouse
- Type: Llama VHH
- Application: ELISA, IHC, FC, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB, Indirect ELISA
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- Target: IL2
- Species Reactivity: Mouse
- Cytokine 1: IL2
- Host: Rat
- Cytokine 1 Species: Mouse
- Molecule Class: L Kappa; IL2-IgG2a
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, FuncS
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- Species Reactivity: Mouse
- Type: Human IgG1
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Mouse
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Mouse
- Type: Human scFv
- Application: ELISA, FC
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
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- Species Reactivity: Mouse
- Type: Human IgG1
- Application: ELISA, FC, Inhib, FuncS
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- Species Reactivity: Mouse
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Mouse
- Type: Human scFv
- Application: ELISA, FC
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.