Anti-CEACAM1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides top-tier anti-CEACAM1 recombinant antibodies to study the emerging role of this novel immune checkpoint and adhesion molecule in regulating T-cell function and tumor immunity. Our superior antibodies are critical tools to explore its function as an immunotherapy target and to examine its role in cell adhesion and angiogenesis.

CEACAM1: An Immunosuppressive Checkpoint and Adhesion Molecule

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1), also known as CD66a, is a transmembrane glycoprotein that serves a dual role. It functions in both cell-cell adhesion through homophilic and heterophilic interactions. It is also a recently discovered key inhibitory immune checkpoint. CEACAM1 is expressed on activated T-cells, NK cells, and other immune cell types. When it binds to CEACAM1 on other cells, including tumor cells that often overexpress it, it sends a strong inhibitory signal that dampens T-cell activation, proliferation, and anti-tumor effector function. Blockade of the CEACAM1 pathway is a highly attractive and novel strategy for cancer immunotherapy.

Alternative Names

Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1; BGP-1; CD antigen CD66a; CEACAM1; BGP; BGP1

Background

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

Anti-CEACAM1 rAb Products

Creative Biolabs’ anti-CEACAM1 recombinant antibodies are designed to have high affinity and superior blocking activity. They are also carefully validated to detect CEACAM1 accurately on immune cells and tumor cell surfaces. Optimized for use in multi-color flow cytometry, functional T-cell activation assays, and IHC on tumor tissues, our rAbs are the ideal tools for immuno-oncology drug discovery.

Table 1. Featured anti-CEACAM1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to supporting the development of next-generation cancer therapies. Our internal quality control ensures that every lot of anti-CEACAM1 recombinant antibody is validated for purity, binding kinetics, and functional performance in blocking assays. With Creative Biolabs, you can trust that you are getting a high-quality reagent that you can rely on.

Fig.1 IHC analysis of anti-CEACAM1 antibody (Cat# ZG-0082U, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs has advanced antibody production platforms to help move immuno-oncology research forward. Our anti-CEACAM1 recombinant antibodies are produced in highly optimized mammalian cell lines to ensure proper glycosylation and a native antibody conformation for maximum functional activity.

Featured Anti-CEACAM1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CEACAM1 recombinant antibody production.

Fig.3 Gram-scale anti-CEACAM1 recombinant antibody production.

rAb Modalities

Creative Biolabs prides itself on being a flexible and innovative partner for cancer research. We offer a range of modalities for our anti-CEACAM1 recombinant antibodies that are customizable, such as different isotypes and Fab fragments, so that researchers all over the world can study this important immune checkpoint.

Fig.4 Full-length anti-CEACAM1 recombinant antibody production and modalities.

CEACAM1-Targeted Drug Information

Table 2. Public drug targeting CEACAM1.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Unlock the potential of CEACAM1 with Creative Biolabs’ superior recombinant antibodies. Defined by stringent validation and functional activity, our portfolio has the ideal tools to advance your next-generation immunotherapy project. Partner with us today for the quality you need to make an impact. Contact our technical experts now.