Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Intracellular, Membrane (different isoforms)
Group enriched (Horizontal cells, Hepatocytes)
Not detected in immune cells
Cell line enriched (U-2 OS)
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-4-beta-2 interacts with alpha-conotoxins PnIA, GID and MII (By similarity).
Ion channel, Ligand-gated ion channel, Receptor
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For Research Use Only. Not For Clinical Use.