Plasma proteins, Transcription factors
Intracellular
Group enriched (Late spermatids, Early spermatids, Erythroid cells)
Immune cell enhanced (basophil)
Cell line enhanced (Daudi, Karpas-707, U-266/84, U-698)
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Binds EAPP.
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.