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EIF3D
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. (Microbial infection) Interacts with Norwalk virus VPg protein (PubMed:12773399).
Molecular function
Initiation factor, RNA-binding
More Types Infomation
- PE-B*15:01/Human EIF3D (SQFGGGSQY) MHC Tetramer (MHC-LC4376)
-
- Class: Class I
- Antigen: EIF3D
- Antigen Species: Human
- Peptide: SQFGGGSQY
- Conjugate: PE
- PE-B*27:05/Human EIF3D (SQFGGGSQY) MHC Tetramer (MHC-LC4375)
-
- Class: Class I
- Antigen: EIF3D
- Antigen Species: Human
- Peptide: SQFGGGSQY
- Conjugate: PE
- PE-A*11:01/Human EIF3D (SQFGGGSQY) MHC Tetramer (MHC-LC4374)
-
- Class: Class I
- Antigen: EIF3D
- Antigen Species: Human
- Peptide: SQFGGGSQY
- Conjugate: PE
- PE-A*03:01/Human EIF3D (SQFGGGSQY) MHC Tetramer (MHC-LC4373)
-
- Class: Class I
- Antigen: EIF3D
- Antigen Species: Human
- Peptide: SQFGGGSQY
- Conjugate: PE
- PE-A*02:01/Human EIF3D (ALLAGSEYL) MHC Tetramer (MHC-LC1927)
-
- Class: Class I
- Antigen: EIF3D
- Antigen Species: Human
- Peptide: ALLAGSEYL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.