Plasma proteins, RAS pathway related proteins, Transcription factors
Intracellular
Cell type enhanced (NK-cells, dendritic cells, T-cells, Adipocytes, Hepatic stellate cells, Endothelial cells)
Low immune cell specificity
Cell line enhanced (HEL, JURKAT, U-698)
Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.
DNA-binding
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For Research Use Only. Not For Clinical Use.