FN1
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.
Species Reactivity: Human
Type: Mouse antibody
Application: ELISA
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG2b, κ
Application: IHC, IP, WB
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Species Reactivity: Rat, Chicken, Bovine, Canine, Human, Porcine, Monkey
Type: Mouse IgG1
Application: WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA, WB, IP, Block
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Derivation: Phage display library
Species Reactivity: Human
Type: Rabbit IgG
Application: IHC-Fr, IHC-P, IHC-P, IP, WB
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Species Reactivity: Human
Type: Rabbit IgG
Application: WB, IF, IHC
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Species Reactivity: Human, Mouse
Type: Human scFv
Application: ELISA, IHC
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Species Reactivity: Human, Mouse
Type: Human IgG
Application: ELISA, IHC
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Species Reactivity: Human, Mouse
Type: Human Fab
Application: ELISA, IHC
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Species Reactivity: Human
Type: Mouse antibody
Application: ELISA, WB
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Species Reactivity: Human, Mouse
Type: Mouse Fab
Application: ELISA, FC, IHC
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Species Reactivity: Human, Mouse
Type: Mouse Fab
Application: ELISA, FC, IHC
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Humanized Fab
Application: ELISA, FC, IHC
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Humanized Fab
Application: ELISA, FC, IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Humanized IgG
Application: ELISA, FC, IHC
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Humanized IgG
Application: ELISA, FC, IHC
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Species Reactivity: Human, Mouse
Type: Mouse IgG1
Application: ELISA, FC, IHC
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, IHC
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, FC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human Fab
Application: IHC
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Species Reactivity: Human
Type: Human scFv
Application: IHC
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Human scFv
Application: ELISA, FC, IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human
Type: Human IgG
Application: IHC
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Species Reactivity: Human, Mouse
Type: Mouse IgG1
Application: ELISA, FC, IHC
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, IHC, WB
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Derivation: Humanized
Species Reactivity: Human, Mouse
Type: Human scFv
Application: ELISA, FC, IHC
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Species Reactivity: Human, Mouse
Type: Mouse scFv
Application: ELISA, FC, IHC
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Species Reactivity: Human, Mouse
Type: Mouse scFv
Application: ELISA, FC, IHC
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Target: EDB
Species Reactivity: Human
Cytokine 1: TNFα
Host: Human
Cytokine 1 Species: Mouse
Molecule Class: scFv-TNFα
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Target: EDB
Species Reactivity: Human
Cytokine 1: TNFα
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-TNFα
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Target: EDB
Species Reactivity: Human
Cytokine 1: GM-CSF
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-GM-CSF
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL15
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-IL15
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Target: EDB
Species Reactivity: Human
Cytokine 1: GM-CSF
Host: Human
Cytokine 1 Species: Human
Molecule Class: GM-CSF-scFv-scFv-GM-CSF
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Human
Cytokine 1 Species: Human
Molecule Class: scIL12-scFv-CH4
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Target: Fibronectin
Linker: disulfide linker
Drug: CemCH2-SH
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Derivation: Human
Species Reactivity: Human
Type: [(scFv - heavy - kappa) - IGHE - CH4]2
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, IHC, WB
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Species Reactivity: Human
Type: Human antibody
Application: ELISA, WB
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Derivation: ETH-2 library
Species Reactivity: Human
Type: Human antibody
Application: ELISA, IHC
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Species Reactivity: Human
Type: Human antibody
Application: ELISA, WB
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Derivation: ETH-2 library
Species Reactivity: Human
Type: Human antibody
Application: ELISA, IHC
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Derivation: HuCAL®Gold phages
Species Reactivity: Human
Type: Human antibody
Application: ELISA, BL, IHC
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Derivation: Human scFv phage library
Species Reactivity: Human
Type: Human Antibody
Application: ELISA, WB
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Derivation: Human scFv phage library
Species Reactivity: Human
Type: Human Antibody
Application: ELISA, WB
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, IHC, WB
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Species Reactivity: Human
Type: Human antibody
Application: ELISA, WB
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Derivation: ETH-2 library
Species Reactivity: Human
Type: Human antibody
Application: ELISA, IHC
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Derivation: HuCAL®Gold phages
Species Reactivity: Human
Type: Human antibody
Application: ELISA, Block, IHC
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Derivation: HuCAL®Gold phages
Species Reactivity: Human
Type: Human antibody
Application: ELISA, BL, IHC
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Derivation: Human scFv phage library
Species Reactivity: Human
Type: Human Antibody
Application: ELISA, WB
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Target: EDB
Species Reactivity: Human
Cytokine 1: scIL12
Host: Humanized from Mouse
Cytokine 1 Species: Human
Molecule Class: IgG3-scIL12
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Target: fibronectin
Linker: disulfide linkers
Drug: DM1-SH(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine-SH)
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Target: fibronectin
Linker: disulfide linkers
Drug: DM1-SH(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine-SH)
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Human
Cytokine 1 Species: Mouse
Molecule Class: p40-scFv-scFv-p35
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Target: EDB
Species Reactivity: Human
Cytokine 1: GM-CSF
Host: Human
Cytokine 1 Species: Mouse
Molecule Class: GM-CSF-scFv
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL2
Host: Human
Cytokine 1 Species: Human
Molecule Class: IL2-scFv
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL2
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-IL2
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-IL12-scFv
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Human
Cytokine 1 Species: Human
Molecule Class: IL12-scFv
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-CH4-IL12
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Humanized from Mouse
Cytokine 1 Species: Human
Molecule Class: IgG1-IL12
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL12
Host: Humanized from Mouse
Cytokine 1 Species: Mouse
Molecule Class: IgG1-IL12
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL10
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-IL10
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Target: EDB
Species Reactivity: Human
Cytokine 1: IFNγ
Host: Human
Cytokine 1 Species: Mouse
Molecule Class: scFv-IFNγ
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Target: EDB
Species Reactivity: Human
Cytokine 1: GM-CSF
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-GM-CSF
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Target: EDB
Species Reactivity: Human
Cytokine 1: VEGF
Host: Human
Cytokine 1 Species: Human
Molecule Class: scFv-VEGF
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Target: EDB
Species Reactivity: Human
Cytokine 1: IL4
Host: Human
Cytokine 1 Species: Mouse
Molecule Class: scFv-IL4
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Scaffold Name: Ubiquitin
Target: FN1
Species Reactivity: Human
Derivation: Phage display
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Target: EDB
Species Reactivity: Human
Cytokine 1: TNFα
Cytokine 2: IL12
Host: Human
Cytokine 1 Species: Human
Cytokine 2 Species: Human
Molecule Class: scIL12-scFv-TNFα
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Scaffold Name: Kunitz domains
Target: Fibronectin (α5β1)
Species Reactivity: Human
Derivation: Phage display
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Scaffold Name: Aptide
Target: Fibronectin extra domain B (EDB)
Species Reactivity: Human
Derivation: Phage display
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Scaffold Name: Anastellin/FN3
Target: Fibronectin
Species Reactivity: Human
Derivation: Phage display
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