FcγRI & CD33
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
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- Targets: FcγRI & CD33
- Type: CrossMab
- Application: FuncS, Promising therapeutic agent
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- Class: Class I
- Antigen: CD33
- Antigen Species: Human
- Peptide: AIISGDSPV
- Conjugate: PE
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- Class: Class I
- Antigen: CD33 A65Y
- Antigen Species: Human
- Peptide: YIISGDSPV
- Conjugate: APC
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- Class: Class I
- Antigen: CD33
- Antigen Species: Human
- Peptide: AIISGDSPV
- Conjugate: APC
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- Class: Class I
- Antigen: CD33 A65Y
- Antigen Species: Human
- Peptide: YIISGDSPV
- Conjugate: PE
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, IF, IHC, IP, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, IHC-Fr, ICC, IP, WB, Block
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IP
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1, κ
- Application: ELISA, IHC, FC, IP, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC, FuncS
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, IP, ChiP, Neut, ELISA
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG4, κ
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: Asn73 in FR of VH
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- Type: Human antibody
- Application: FC
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- Type: Human antibody
- Application: FC
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- Type: Human antibody
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, Cyt
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Target: CD33
- Linker: VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Target: CD33
- Linker: mc-VC (maleimidocaproyl-valine-citrulline)
- Drug: pyrrolobenzodiazepine (PBD) dimers
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, Cyt
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, IF, RIA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, IF, RIA
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- Target: CD33
- Linker: SPDB
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, IF, RIA
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- Target: CD33
- Linker: hydrazone
- Drug: Calicheamicin
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- Target: CD33
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: CD33
- Linker: DOTA-SH
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- Target: CD33
- Linker: mc-VC (maleimidocaproyl-valine-alanine)
- Drug: pyrrolobenzodiazepine (PBD) dimers
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- Target: CD33
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: CD33
- Linker: mc-vc (maleimidocaproyl-valine-alanine)
- Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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- Target: CD33
- Linker: DOTA-NCS
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- Target: CD33
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: CD33
- Linker: DOTA-G3FC
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- Target: CD33
- Linker: acetyl butyrate linker
- Drug: calicheamicin
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- Target: CD33
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: Calicheamicin
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- Target: CD33
- Linker: AcBut
- Drug: Calicheamicin
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- Target: CD33
- Drug: calicheamicin
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
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