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FcγRII & CD79B

Engineered Antibody MHC
CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
FcγRII & CD79B
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
  • Anti-cyCD79b (clone 10D10)-MCC-DM1 ADC (ADC-216LZY)
    • Target: cyCD79b
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate))
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD79b (clone SN8)-MCC-DM1 ADC (ADC-202LZY)
    • Target: CD79b
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD79b (clone SN8)-SPP-DM1 ADC (ADC-201LZY)
    • Target: CD79b
    • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD79b-mc-MMAF ADC (ADC-085LZY)
    • Target: CD79b
    • Linker: mc(maleimidocaproyl)
    • Drug: MMAF(monomethyl auristatin F)
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  • Anti-CD79b-MCC-DM1 ADC (ADC-084LZY)
    • Target: CD79b
    • Linker: MCC (4-(Nmaleimidomethyl)cyclohexane-1 carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD79b-vc-MMAE ADC (ADC-034LZY)
    • Target: CD79b
    • Linker: VC(Valine-citrulline)
    • Drug: MMAE (monomethyl auristatin E)
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  • Anti-CD79 (bSN8)-mcc-DM1 ADC (ADC-089LCT)
    • Target: CD79b
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD79b (clone hu2F2.D7)-SMCC-DM1 ADC (ADC-203CL)
    • Target: CD79b
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC (ADC-202CL)
    • Target: CD79b
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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