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Gdf9

Anti-Gdf9 Products
- Rat Anti-Gdf9 Recombinant Antibody (clone CBL655) (NEUT-869CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Neut
- Anti-GDF9 Immunohistochemistry Kit (VS-0325-XY909)
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- Species Reactivity: Human, Mouse, Rat
- Target: GDF9
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis.

Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Early spermatids, Spermatocytes, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (JURKAT)
Interaction
Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).
Molecular function
Cytokine, Growth factor
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