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HEY1

Anti-HEY1 Products

Recombinant Mouse anti-Human HEY1 Monoclonal antibody (EML1394) (MOB-0898CT)
- Species Reactivity: Human
- Application: WB
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Chicken Anti-HEY1 Polyclonal IgY (BRD-1071MZ)
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ELISA, WB
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Anti-HEY1 Immunohistochemistry Kit (VS-0525-XY3126)
- Species Reactivity: Human
- Target: HEY1
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Protein class

Cancer-related genes, Transcription factors, Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Adipocytes, Skeletal myocytes, Endothelial cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (HEK93, PC-3, SK-MEL-30, WM-115)

Interaction

Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.

Molecular function

Developmental protein, DNA-binding, Repressor

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Related Diseases

Breast Cancer