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    HGF

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.
    HGF
    Protein class

    Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, RAS pathway related proteins

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Fibroblasts, Muller glia cells, Smooth muscle cells, Hepatic stellate cells, Endometrial stromal cells)

    Immune cell specificity

    Immune cell enriched (basophil)

    Cell line specificity

    Cell line enhanced

    Interaction

    Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Molecular function

    Growth factor, Serine protease homolog

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