HLA-DRB1
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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- Species Reactivity: Human
- Application: Cyt, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, IHC, IF, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, IF, FuncS
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IP, FC, FuncS, Neut, IF
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Human IgG
- Application: Cyt, WB
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB
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- Species Reactivity: Human, Mouse
- Type: Human IgG
- Application: Cyt, WB
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: Cyt, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: Cyt, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
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- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
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- Type: Mouse IgG1
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, WB, EM, Cyt
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: Cyt, WB
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: Cyt, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB
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