HTT
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats.
Derivation: Mouse
Species Reactivity: Human
Type: IgG
Application: WB, Neut, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: scFv
Application: FC, Neut, Funcs
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Species Reactivity: Human
Type: Human scFv
Application: FC, ELISA
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Species Reactivity: Human
Type: Human scFv
Application: Block
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Derivation: Human
Species Reactivity: Human
Type: scFv
Application: ELISA, WB, FuncS
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Derivation: Human
Species Reactivity: Human
Type: Fab
Application: Neut, WB, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: Fab
Application: IP, IF, FuncS
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Species Reactivity: Human
Type: Human VL
Application: ELISA, FuncS
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Species Reactivity: Human
Type: Human Fab
Application: FC, ELISA
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Species Reactivity: Human
Type: Human Fab
Application: Block
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Derivation: Human
Species Reactivity: Human
Type: IgG
Application: WB, Neut, FuncS
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: WB, IHC, FC, IF
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Species Reactivity: Human
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Derivation: Human
Species Reactivity: Human
Type: Fab
Application: WB, Neut, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: Fab
Application: WB, ELISA, FuncS
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Species Reactivity: Human
Type: Human IgG
Application: FC, ELISA
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Species Reactivity: Human
Type: Human IgG
Application: Block
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Derivation: Mouse
Species Reactivity: Human
Type: scFv
Application: WB, ELISA, FuncS
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Derivation: Human
Species Reactivity: Human
Type: scFv
Application: WB, Neut, FuncS
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Derivation: Phage display library
Species Reactivity: Human
Type: Rabbit IgG
Application: WB, IHC-P, ICC
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Species Reactivity: Human
Application: Dot, WB
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Derivation: Human
Species Reactivity: Human
Type: IgG
Application: WB, Neut, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: IgG
Application: WB, ELISA, FuncS
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Species Reactivity: Human
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: FC, ICC, IHC, WB
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Human scFv
Application: ELISA
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Species Reactivity: Human
Type: Human Fab
Application: ELISA
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, DB, IHC, FuncS
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Species Reactivity: Human
Type: Human IgG1, κ
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse IgG2a
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse IgG2a
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse IgG2a
Application: ELISA, WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, IHC
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Species Reactivity: Human, Mouse
Type: Mouse IgG2a
Application: IHC, WB, Inhib
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Species Reactivity: Human, Mouse
Type: Mouse IgM
Application: FuncS, WB, Inhib, IHC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, WB
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Species Reactivity: human
Type: scFv-Tat
Application: WB, CO-IP, FuncS
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Species Reactivity: human
Type: scFv-(+36GFP)
Application: IF, FC, WB, FuncS
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Species Reactivity: human
Type: scFv-(D-Arg)9
Application: ELISA, WB, ICC, FuncS
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Species Reactivity: Human
Type: Rabbit IgG
Application: ELISA, IHC
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, WB
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Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: ELISA, IHC
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Species Reactivity: Human
Type: Llama VHH
Application: IHC, ICC, FC, FA, FUNC
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Species Reactivity: Human, Mouse
Type: Mouse Fab
Application: ELISA, FC, WB, IHC
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Derivation: Phage display library
Species Reactivity: Human, Mouse
Type: Mouse Fab
Application: ELISA, FC, WB, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: ELISA, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: ELISA, IHC
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Species Reactivity: Human, Mouse
Type: Mouse Fab
Application: ELISA, FC, WB, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: ELISA, IHC
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Species Reactivity: Human, Mouse
Type: Mouse scFv
Application: ELISA, FC, WB, IHC
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Species Reactivity: Human, Mouse
Type: Mouse scFv
Application: ELISA, FC, WB, IHC
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Derivation: Phage display library
Species Reactivity: Human, Mouse
Type: Mouse scFv
Application: ELISA, FC, WB, IHC
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For Research Use Only. Not For Clinical Use.