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IGF1

Anti-IGF1 Products

dAbs scaffold protein anti-human Insulin-like growth factor (IGF) (SDS-L075)
- Scaffold Name: dAbs
- Target: Insulin-like growth factor (IGF)
- Species Reactivity: human
- Derivation: Phage display
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Z-domain of protein A scaffold protein anti-Human Insulin (SZA-L233)
- Scaffold Name: Z-domain of protein A
- Target: Insulin
- Species Reactivity: Human
- Derivation: Phage display
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More Infomation

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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Protein class

Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Endometrial stromal cells, Leydig cells)

Immune cell specificity

Immune cell enhanced (naive B-cell)

Cell line specificity

Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)

Interaction

Forms a ternary complex with IGFR1 and ITGAV:ITGB3 (PubMed:19578119). Forms a ternary complex with IGFR1 and ITGA6:ITGB4 (PubMed:22351760, PubMed:23696648). Interacts with SH2D3C isoform 2 (PubMed:20881139).

Molecular function

Growth factor

More Types Infomation

Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance