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IL17 & TNF

Anti-IL17 & TNF Products

Anti-Human TNF Recombinant Antibody (Infliximab) (TAB-006)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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Anti-Human TNF Recombinant Antibody (TAB-010) (TAB-010)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1, κ
- Application: WB, FC, IP, ELISA, Neut, FuncS, IF
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Anti-Human TNF alpha Recombinant Antibody Fab Fragment (TAB-034-F(E)) (TAB-034-F(E))
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab'
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
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Anti-Human IL-17 Recombinant Antibody Fab Fragment (CAT-2200) (TAB-077ZJ-F(E))
- Species Reactivity: Cynomolgus monkey, Canine, Human
- Type: Human antibody
- Application: ELISA, WB, Inhib, Neut
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Human Anti-IL17 Recombinant Antibody; Fab Fragment (TAB-081ZJ-F(E)) (TAB-081ZJ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody Fab Fragment (c632.1) (TAB-082ZJ-F(E))
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (clone A2) (PABL-349)
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, FuncS
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Anti-Human IL-17 Recombinant Antibody (TAB-047ZJ) (TAB-047ZJ)
- Species Reactivity: Cynomolgus monkey, Marmoset monkey, Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (TAB-400CQ) (TAB-400CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (TAB-401CQ) (TAB-401CQ)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (TAB-402CQ) (TAB-402CQ)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody Fab Fragment (TAB-047ZJ-F(E)) (TAB-047ZJ-F(E))
- Species Reactivity: Cynomolgus monkey, Marmoset monkey, Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (TAB-404CQ) (TAB-404CQ)
- Species Reactivity: Human, Cynomolgous monkey
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-396CQ-S(P)) (TAB-396CQ-S(P))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-397CQ-S(P)) (TAB-397CQ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-398CQ-S(P)) (TAB-398CQ-S(P))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-399CQ-S(P)) (TAB-399CQ-S(P))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-400CQ-S(P)) (TAB-400CQ-S(P))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-401CQ-S(P)) (TAB-401CQ-S(P))
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) (TAB-402CQ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-404CQ-S(P)) (TAB-404CQ-S(P))
- Species Reactivity: Human, Cynomolgous monkey
- Type: Human antibody
- Application: ELISA, WB
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Anti-Human TNF Recombinant Antibody scFv Fragment (XENP6401) (TAB-405CQ-S(P))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody Fab Fragment (CDP571) (TAB-110CQ-F(E))
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody Fab Fragment (B5) (TAB-111CQ-F(E))
- Species Reactivity: Human, Mouse, Chimpanze
- Type: Human antibody
- Application: ELISA, WB
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Anti-Human TNF Recombinant Antibody (XENP6401) (TAB-405CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) (TAB-113CQ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-114CQ-F(E)) (TAB-114CQ-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, Neut
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-131CQ-F(E)) (TAB-131CQ-F(E))
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (TAB-254) (TAB-254)
- Derivation: Human
- Species Reactivity: Human
- Type: [V-kappa]2 - Fc
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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Mouse Anti-TNF Recombinant Antibody (clone 18C3) (MOB-1076z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, FuncS
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Anti-Human IL-17 Recombinant Antibody scFv Fragment (TAB-047ZJ-S(P)) (TAB-047ZJ-S(P))
- Species Reactivity: Cynomolgus monkey, Marmoset monkey, Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody scFv Fragment (CAT-2200) (TAB-077ZJ-S(P))
- Species Reactivity: Cynomolgus monkey, Canine, Human
- Type: Human antibody
- Application: ELISA, WB, Inhib, Neut
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Human Anti-IL17 Recombinant Antibody; scFv Fragment (TAB-081ZJ-S(P)) (TAB-081ZJ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody scFv Fragment (c632.1) (TAB-082ZJ-S(P))
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (CDP571) (TAB-110CQ)
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (B5) (TAB-111CQ)
- Species Reactivity: Human, Mouse, Chimpanze
- Type: Human antibody
- Application: ELISA, WB
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Anti-Human TNF Recombinant Antibody (TAB-396CQ) (TAB-396CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (TAB-397CQ) (TAB-397CQ)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (TAB-398CQ) (TAB-398CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (TAB-114CQ) (TAB-114CQ)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, FC, Inhib
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Human Anti-TNF Recombinant Antibody (TAB-115CQ) (TAB-115CQ)
- Derivation: Humanized
- Species Reactivity: Human, Rhesus macaque, Cynomolgus, Canine
- Type: Humanized antibody
- Application: ELISA, FC, Neut
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Anti-Human TNF Recombinant Antibody (TAB-118CQ) (TAB-118CQ)
- Species Reactivity: Human
- Type: Humanized antibody
- Application: FC, ELISA
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Human Anti-TNF Recombinant Antibody (TAB-119CQ) (TAB-119CQ)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, BL
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Anti-Human TNF Recombinant Antibody (TAB-120CQ) (TAB-120CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Neut
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Afuco™ Anti-Human TNF ADCC Recombinant Antibody (AVX-470), ADCC Enhanced (AFC-601CL)
- Derivation: Cow
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Anti-Human TNF Recombinant Antibody (TAB-399CQ) (TAB-399CQ)
- Species Reactivity: Human
- Type: Human antibody
- Application: WB
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Anti-Human TNF Recombinant Antibody Fab Fragment (G1) (TAB-140CQ-F(E))
- Species Reactivity: Human
- Type: Human antibody
- Application: FC, Neut
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-141CQ-F(E)) (TAB-141CQ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-142CQ-F(E)) (TAB-142CQ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-143CQ-F(E)) (TAB-143CQ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut
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Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-396CQ-F(E)) (TAB-396CQ-F(E))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody Fab Fragment (XENP6401) (TAB-405CQ-F(E))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody Fab Fragment (2SD4) (TAB-133CQ-F(E))
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Neut
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Anti-Human TNF Recombinant Antibody Fab Fragment (hMAK195) (TAB-134CQ-F(E))
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized antibody
- Application: ELISA, Neut
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Anti-Human TNF Recombinant Antibody Fab Fragment (AE11-5) (TAB-135CQ-F(E))
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: ELISA, Neut
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-136CQ-F(E)) (TAB-136CQ-F(E))
- Species Reactivity: Human, Rabbit
- Type: Human Fab
- Application: ELISA, Block
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-137CQ-F(E)) (TAB-137CQ-F(E))
- Species Reactivity: Human, Cynomolgous macaque
- Type: Human Fab
- Application: ELISA, FC, IF
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Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-138CQ-F(E)) (TAB-138CQ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IF
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Anti-Human TNF Recombinant Antibody scFv Fragment (CDP571) (TAB-110CQ-S(P))
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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Anti-Human TNF Recombinant Antibody scFv Fragment (B5) (TAB-111CQ-S(P))
- Species Reactivity: Human, Mouse, Chimpanze
- Type: Human antibody
- Application: ELISA, WB
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Rabbit Anti-TNF Recombinant Antibody; scFv Fragment (TAB-271CQ-S(P)) (TAB-271CQ-S(P))
- Species Reactivity: Human
- Type: Rabbit scFv
- Application: ELISA, WB
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Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (TAB-139CQ-F(E)) (TAB-139CQ-F(E))
- Species Reactivity: Human
- Type: Rabbit Fab
- Application: ELISA, FC, IF
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Mouse Anti-IL17 Recombinant Antibody; Fab Fragment (TAB-028ZJ-F(E)) (TAB-028ZJ-F(E))
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-IL17 Recombinant Antibody; scFv Fragment (TAB-027ZJ-S(P)) (TAB-027ZJ-S(P))
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Human Anti-TNF Recombinant Antibody (clone A2); scFv Fragment (PSBL-349)
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FuncS
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Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment (PFBL-349)
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FuncS
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Mouse Anti-IL17 Recombinant Antibody (TAB-028ZJ) (TAB-028ZJ)
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody (TAB-029ZJ) (TAB-029ZJ)
- Species Reactivity: Human
- Application: ELISA
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Mouse Anti-IL17 Recombinant Antibody; Fab Fragment (TAB-027ZJ-F(E)) (TAB-027ZJ-F(E))
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (Vh5/Vk12) (TAB-116CQ)
- Species Reactivity: Human
- Application: ELISA
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Anti-Human TNF Recombinant Antibody (TAB-117CQ) (TAB-117CQ)
- Species Reactivity: Human
- Application: ELISA, WB
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Anti-Human TNF Recombinant Antibody (A10G10) (TAB-112CQ)
- Species Reactivity: Human
- Application: Neut, ELISA, WB
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10-FnIII scaffold protein anti-Human TNFα (SFN-L026)
- Scaffold Name: 10-FnIII
- Target: TNFα
- Species Reactivity: Human
- Derivation: mRNA Display
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Anti-TNF alpha Recombinant Antibody (TAB-768) (TAB-768)
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG1
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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Recombinant Anti-human TNF VHH Single Domain Antibody (NABL-051)
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA, IHC, FC, FuncS
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Anti-TNFα Recombinant Antibody (TAB-718) (TAB-718)
- Derivation: Mouse
- Species Reactivity: Human
- Type: F(ab')2 - G3 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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Bovine Anti-TNF Recombinant Antibody (TAB-623CL) (TAB-623CL)
- Species Reactivity: Human
- Type: Bovine IgG
- Application: Neut
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Kunitz domains scaffold protein anti-Human TNFα (SKD-L116)
- Scaffold Name: Kunitz domains
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
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Ubiquitin scaffold protein anti-TNFα (SUB-L209)
- Scaffold Name: Ubiquitin
- Target: TNFα
- Derivation: Phage display
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Mouse Anti-IL17 Recombinant Antibody (TAB-027ZJ) (TAB-027ZJ)
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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Anti-Human TNF Recombinant Antibody Fab Fragment (MAK195) (TAB-132CQ-F(E))
- Species Reactivity: Human
- Application: ELISA, Neut
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Anti-Human TNF Single Domain Antibody (TAB-412CQ), Research Grade Biosimilar (TAB-412CQ)
- Species Reactivity: Human, Mouse
- Type: Single domain antibody
- Application: ELISA, Inhib
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Anti-Human TNF Single Domain Antibody (TAB-413CQ), Research Grade Biosimilar (TAB-413CQ)
- Species Reactivity: Human, Rat
- Type: Single domain antibody
- Application: ELISA, WB, Neut
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Anti-Human TNF Single Domain Antibody (TAB-414CQ), Research Grade Biosimilar (TAB-414CQ)
- Species Reactivity: Human, Rat
- Type: Single domain antibody
- Application: ELISA, WB, Neut
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Anti-Human TNF Single Domain Antibody (TAB-415CQ), Research Grade Biosimilar (TAB-415CQ)
- Species Reactivity: Human, Rat
- Type: Single domain antibody
- Application: ELISA, WB, Neut, FunS
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Anti-Human TNF Recombinant Antibody Fab Fragment (A10G10) (TAB-112CQ-F(E))
- Species Reactivity: Human
- Application: ELISA, WB
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Z-domain of protein A scaffold protein anti-Human TNFα (SZA-L241)
- Scaffold Name: Z-domain of protein A
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
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Mouse Anti-IL17 Recombinant Antibody; Fab Fragment (TAB-031ZJ-F(E)) (TAB-031ZJ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-IL17 Recombinant Antibody; scFv Fragment (TAB-028ZJ-S(P)) (TAB-028ZJ-S(P))
- Derivation: HC & LC phage library
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody Fab Fragment (TAB-029ZJ-F(E)) (TAB-029ZJ-F(E))
- Species Reactivity: Human
- Application: ELISA
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Anti-Human IL-17 Recombinant Antibody scFv Fragment (TAB-029ZJ-S(P)) (TAB-029ZJ-S(P))
- Species Reactivity: Human
- Application: ELISA
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Mouse Anti-IL17 Recombinant Antibody; scFv Fragment (TAB-031ZJ-S(P)) (TAB-031ZJ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-IL17 Recombinant Antibody (TAB-031ZJ) (TAB-031ZJ)
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA
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Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ) (TAB-271CQ)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, Neut
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Recombinant Anti-IL17 × Anti-TNF Bispecific Antibody (CrossMab) (CROSS-L017)
- Targets: IL17 & TNF
- Type: CrossMab
- Application: FuncS, Promising therapeutic agent
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Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) (Gly-083LC)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Non-hyper galactosylated
- Glycosylation site: Asn297 at Fc region
- Glycoform (ratio): G0F (68%)
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Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) (Gly-083LC-1)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Non-hyper galactosylated
- Glycosylation site: Asn297 at Fc region
- Glycoform (ratio): G0F (68%)
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Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) (Gly-085LC)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Sialylated
- Glycosylation site: Asn297 at Fc region
- Glycoform (ratio): G2S1F and G2S2F
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Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) (Gly-085LC-1)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Sialylated
- Glycosylation site: Asn297 at Fc region
- Glycoform (ratio): G2S1F and G2S2F
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Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) (Gly-086LC-1)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Fc glycosylation/Hyper-galactosylated
- Glycosylation site: Asn297 at Fc region
- Glycoform (ratio): G1F/G2F (80%)
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Related Diseases

Asthma

Inflammatory Bowel Diseases

Rheumatoid Arthritis

Related Signaling Pathways

TNF Signaling Pathway