IL4 & IL13
Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).
Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).
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- Targets: IL4 & IL13
- Type: Tandem Diabody
- Application: FuncS, Promising therapeutic agent
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- Species Reactivity: Human
- Application: WB, Neut
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: WB, ELISA, FuncS
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: WB, ELISA, FuncS
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, Neut
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Neut
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, Neut
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: Neut
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, Neut
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: Neut
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Human IgG
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, Neut, WB
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: Neut
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, WB
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- Species Reactivity: Feline
- Type: Mouse IgG2a
- Application: WB, ELISA, Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, FC, IP
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- Species Reactivity: Canine
- Type: Mouse IgG1
- Application: Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, ELISPOT, Neut
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Species Reactivity: Human
- Application: ELISA, Neut, WB
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- Species Reactivity: Human
- Type: Rat IgG1
- Application: Block, ELISA, IHC, WB
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- Species Reactivity: Human, Non-Human Primate
- Type: Rat IgG1
- Application: Neut
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Neut, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, IF, Neut, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, CyTOF, Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, CyTOF, ELISA, Neut
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-Fr, ELISA, ELISPOT, Neut
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG, κ
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Block, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: Block, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG, κ
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1, κ
- Application: ELISA, IHC, FC, IP, IF, Inhib
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut, FC
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- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut, FC
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Neut
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Inhib
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Neut, FC
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- Scaffold Name: Ankyrin repeat
- Target: IL4
- Species Reactivity: Human
- Derivation: Ribosome display
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Scaffold Name: Ankyrin repeat
- Target: IL13
- Species Reactivity: Human
- Derivation: Ribosome display
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: WB, ELISA, FC, IP, FuncS, IF, Neut
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG4 - kappa
- Application: ELISA, Neut, IF, IP, FC, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG4 - lambda
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: ELISA, Inhib
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Neut, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Neut
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Neut
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, Inhib
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Neut, FC
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, Neut
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, Neut
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- Species Reactivity: Human
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Neut, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Human antibody
- Application: WB, ELISA, Neut
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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- Species Reactivity: Human
- Application: ELISA
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- Species Reactivity: Human
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, Block
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