INS
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: HLVEALYLV
Conjugate: Unconjugated
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: HLVEALYLV
Conjugate: FITC
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Class: Class I
Antigen: Ins B. 10
Antigen Species: Human
Peptide: HLVEALYLV
Conjugate: Biotin
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: HLVEALYLV
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: HLVEALYLV
Conjugate: APC
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Class: Class II
Antigen: Proinsulin
Antigen Species: Human
Peptide: GAGSLQPLALEGSLQKRG
Conjugate: Biotin
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Class: Class II
Antigen: Proinsulin
Antigen Species: Human
Peptide: GIVEQCCTSICSLYQ
Conjugate: Biotin
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GAGSLQPLALEGSLQKRG
Conjugate: Unconjugated
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: FVNQHLCGSHLVEAL
Conjugate: PE
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GAGSLQPLALEGSLQKRG
Conjugate: FITC
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GAGSLQPLALEGSLQKRG
Conjugate: APC
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GAGSLQPLALEGSLQKRG
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: ALWGPDPAAA
Conjugate: APC
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: LVEALYLVCGERGG
Conjugate: APC
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: LVEALYLVCGERGG
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERG
Conjugate: BV421
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GSLQPLALEGSLQKRG
Conjugate: BV421
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: ALWGPDPAAA
Conjugate: BV421
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: LVEALYLVCGERGG
Conjugate: BV421
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: AQWGPDPAAA
Conjugate: BV421
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: FVNQHLCGSHLVEAL
Conjugate: PE
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: FVNQHLCGSHLVEAL
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERGF
Conjugate: BV421
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: FVNQHLCGSHLVEAL
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERV
Conjugate: BV421
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: FVNQHLCGSHLVEAL
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERGF
Conjugate: APC
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERGF
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERV
Conjugate: APC
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERV
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERG
Conjugate: APC
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: LYLVCGERG
Conjugate: PE
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GSLQPLALEGSLQKRG
Conjugate: APC
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Class: Class II
Antigen: INS
Antigen Species: Human
Peptide: GSLQPLALEGSLQKRG
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: AQWGPDPAAA
Conjugate: APC
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: ALWGPDPAAA
Conjugate: PE
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Class: Class I
Antigen: INS
Antigen Species: Human
Peptide: AQWGPDPAAA
Conjugate: PE
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Species Reactivity: Human
Type: Mouse antibody
Application: ELISA, IHC-Fr
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Species Reactivity: Human
Type: Rabbit IgG
Application: IF, ICC, IHC
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Derivation: Phage display library
Species Reactivity: Human
Type: Rabbit IgG
Application: IHC-P, WB
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Species Reactivity: Human, Mouse, Rat
Type: Mouse IgG1
Application: IHC, ELISA
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: IF, IHC
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Species Reactivity: Mouse
Type: Mouse Fab
Application: ELISA, WB
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Species Reactivity: Mouse
Type: Mouse scFv
Application: ELISA, WB
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Species Reactivity: Human
Type: Rabbit IgG
Application: IHC, FC, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: WB, ELISA, IHC
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Mouse
Type: Mouse IgG2b, κ
Application: ELISA, WB
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Species Reactivity: Bovine
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse scFv
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse IgG2a
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse IgG2a
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse IgG1
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA, FuncS
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FuncS
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FuncS
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Species Reactivity: Bovine
Type: Mouse IgG1
Application: ELISA, FuncS
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA
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Species Reactivity: Bovine
Type: Mouse scFv
Application: ELISA, FuncS
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Species Reactivity: Bovine
Type: Mouse Fab
Application: ELISA, FuncS
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Species Reactivity: Human
Epitope: MLYQHLLPL
MHC: HLA-A*02:01
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Species Reactivity: Human
Epitope: MLYQHLLPL
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human scFv
Application: ELISA
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Species Reactivity: Human
Type: Human Fab, κ
Application: ELISA
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Species Reactivity: Human
Epitope: MLYQHLLPL + OX(M1)
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human IgG1, κ
Application: ELISA
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Species Reactivity: Human
Epitope: MLYQHLLPL + OX(M1)
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human scFv
Application: ELISA
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Epitope: VEALYLVCGEEG
MHC: H2 class II
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Species Reactivity: Human
Type: Human Fab, κ
Application: ELISA
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Species Reactivity: Human
Epitope: YQFGPDFPIA
MHC: HLA-A*02:01
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Species Reactivity: Human
Epitope: YLGGPDFPTI
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human IgG1, κ
Application: ELISA
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Species Reactivity: Human
Epitope: RQWGPDPAAV
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human scFv
Application: ELISA
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Epitope: RQFGPDWIVA
MHC: HLA-A02
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Species Reactivity: Human
Type: Human Fab, κ
Application: ELISA
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Species Reactivity: Human
Epitope: RQFGPDFPTI
MHC: HLA-A*02:01
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Species Reactivity: Human
Type: Human IgG3, κ
Application: ELISA
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Epitope: AQWGPDPAAA
MHC: HLA-A02
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Species Reactivity: Human
Epitope: LYLVCGERG
MHC: H-2Kd
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Species Reactivity: Human
Epitope: ALWGPDPAAA
MHC: HLA-A2
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Species Reactivity: Human
Epitope: GSLQPLALEGSLQKRG
MHC: HLA-DR4
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Species Reactivity: Human
Epitope: ALWGPDPAAA
MHC: HLA-A2
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Species Reactivity: Human
Epitope: GSLQPLALEGSLQKRG
MHC: HLA-DR4
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Species Reactivity: Human
Epitope: ALWGPDPAAA
MHC: HLA-A2
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA
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Species Reactivity: Human
Type: Llama VHH
Application: WB, ICC, ChiP, FA, ELISA
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