ITGAV
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Derivation: Mouse
Species Reactivity: Human
Type: Fab
Application: Neut, FuncS
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Species Reactivity: Human
Application: FC, IHC-Fr, PP
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG2a
Application: ELISA, ICC, IF, IHC, IP, FuncS
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Species Reactivity: Human, African Green Monkey, Rabbit, Bovine
Type: IgG1, κ
Application: FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion
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Species Reactivity: Human
Type: IgG1
Application: Inhib, ICC/IF, BL, FC, ELISA, IP
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA, FuncS
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: WB, FC
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Species Reactivity: Mouse
Type: IgG1, κ
Application: FC, FuncS, IP, Neut
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Species Reactivity: Human
Type: IgG1
Application: CyTOF, BL, FC, IP, ICC
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Species Reactivity: Human
Type: IgG1
Application: ICC/IF, FC, IP, IHC-Fr, BL
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Species Reactivity: Human, Mouse, Rat
Type: IgG2a
Application: IP, FC, BL
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Species Reactivity: Human
Type: IgG2a, κ
Application: FC, IF, ELISA, BL, IP
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Derivation: Phage display library screening
Species Reactivity: Human
Type: IgG
Application: WB, FC
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG
Application: WB, ELISA, FuncS
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Derivation: Mouse
Species Reactivity: Human
Type: scFv
Application: Neut, FuncS
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: WB, ELISA, FC, IHC
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Species Reactivity: Human
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scFv
Application: Cyt, ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scFv
Application: Cyt, ELISA
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, IF
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: WB, FC
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Species Reactivity: Human
Type: Rabbit IgG
Application: ELISA, IHC
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Species Reactivity: Human
Type: Rabbit IgG
Application: ELISA, WB, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, FC, ADCC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ADCC
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Species Reactivity: Human, Mouse, Rat
Type: Rabbit IgG
Application: WB, IHC-P
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Species Reactivity: Human, Rat
Type: Rabbit IgG
Application: WB, ICC, IF, IP
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA, FC, IHC-Fr, IP
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: Cyt, ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: Cyt, ELISA
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Target: αvβ integrin receptor
Species Reactivity: Human
Cytokine 1: IL2
Host: Humanized from Mouse
Cytokine 1 Species: Human
Molecule Class: L Kappa; IL2-IgG2
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Target: αvβ integrin receptor
Species Reactivity: Human
Cytokine 1: IL2
Host: Humanized from Mouse
Cytokine 1 Species: Human
Molecule Class: L Kappa; IgG2-IL2
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: ADCC enhanced antibody
Application: ELISA, IP, FC, FuncS, IF, Neut
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Derivation: Human
Species Reactivity: Human
Type: ADCC enhanced antibody
Application: ELISA, FC, IP, FuncS, IF, Neut
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Target: integrin alphaV
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Derivation: Human
Species Reactivity: Human
Type: IgG1 - kappa
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: IgG2 - kappa
Application: Inhib, Agonist
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Target: Integrin αγ
Linker: SPDB
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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