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ME1
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Excitatory neurons, Muller glia cells, Kupffer cells, Astrocytes, Inhibitory neurons)
Immune cell specificity
Immune cell enriched (MAIT T-cell)
Cell line specificity
Cell line enhanced (CACO-2, OE19)
Interaction
Homotetramer.
Molecular function
Oxidoreductase
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