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MS4A1

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
MS4A1
    • Target: CD20
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    • Target: CD20
    • Linker: mc (maleimidocaproyl)
    • Drug: MMAF (monomethyl auristatin F)
    • Target: CD20
    • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: MMAE (monomethyl auristatin E)
    • Target: CD20
    • Linker: VC (valine-citrulline)
    • Drug: MMAE (Monomethyl auristatin E)
    • Target: CD20
    • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
    • Target: CD20
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
    • Derivation: Chimeric (mouse/human)
    • Species Reactivity: Human
    • Type: IgG1 - kappa
    • Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

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